| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | F9: The Fast Saga | - | - | - | $29,101,290 | 4,203 | $173,005,945 | Jun 25 | Universal Pictures | false |
| 2 | The Boss Baby 2: Family Business | - | - | - | $19,652,550 | 3,688 | $57,300,280 | Jul 2 | Universal Pictures | false |
| 3 | The Forever Purge | - | - | - | $15,762,605 | 3,058 | $44,539,245 | Jul 2 | Universal Pictures | false |
| 4 | A Quiet Place Part II | - | - | - | $5,374,942 | 3,744 | $160,072,261 | May 28 | Paramount Pictures | false |
| 5 | Hitman's Wife's Bodyguard | - | - | - | $3,868,519 | 3,361 | $38,014,727 | Jun 16 | Lionsgate | false |
| 6 | Cruella | - | - | - | $3,154,237 | 3,922 | $86,103,234 | May 28 | Walt Disney Studios Motion Pictures | false |
| 7 | Peter Rabbit 2: The Runaway | - | - | - | $2,838,439 | 3,346 | $40,501,717 | Jun 11 | Sony Pictures Releasing | false |
| 8 | The Conjuring: The Devil Made Me Do It | - | - | - | $1,618,438 | 3,280 | $65,631,050 | Jun 4 | Warner Bros. | false |
| 9 | Zola | - | - | - | $1,552,095 | 1,468 | $4,844,399 | Jun 30 | A24 | false |
| 10 | In the Heights | - | - | - | $1,538,965 | 3,509 | $29,975,167 | Jun 11 | Warner Bros. | false |
| 11 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | - | - | - | $802,054 | 752 | $2,320,649 | Jun 25 | Searchlight Pictures | false |
| 12 | Spirit Untamed | - | - | - | $446,695 | 3,394 | $17,716,215 | Jun 4 | Universal Pictures | false |
| 13 | 12 Mighty Orphans | - | - | - | $335,495 | 1,047 | $3,689,637 | Jun 11 | Sony Pictures Releasing | false |
| 14 | Nobody | - | - | - | $295,925 | 2,567 | $27,568,035 | Mar 26 | Universal Pictures | false |
| 15 | The House Next Door: Meet the Blacks 2 | - | - | - | $110,390 | 539 | $2,893,660 | Jun 11 | Hidden Empire Film Group (HEFG) | false |
| 16 | Queen Bees | - | - | - | $108,804 | 600 | $1,926,706 | Jun 11 | Gravitas Ventures | false |
| 17 | Werewolves Within | - | - | - | $108,527 | 270 | $575,783 | Jun 25 | IFC Films | false |
| 18 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $81,459 | 2,087 | $49,505,008 | Apr 23 | FUNimation Entertainment | false |
| 19 | Wrath of Man | - | - | - | $62,978 | 3,007 | $27,466,489 | May 7 | United Artists Releasing | false |
| 20 | Witnesses | - | - | - | $53,366 | 90 | $855,765 | Jun 4 | Purdie Distribution | false |
| 21 | Raya and the Last Dragon | - | - | - | $48,503 | 2,375 | $54,723,032 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 22 | The Sparks Brothers | - | - | - | $34,800 | 534 | $648,665 | Jun 18 | Focus Features | false |
| 23 | Spiral | - | - | - | $29,719 | 2,991 | $23,216,862 | May 14 | Lionsgate | false |
| 24 | I Carry You with Me | - | - | - | $27,856 | 111 | $166,403 | Jun 25 | Sony Pictures Classics | false |
| 25 | Dream Horse | - | - | - | $19,847 | 1,284 | $2,913,328 | May 21 | Bleecker Street Media | false |
| 26 | Rita Moreno: Just a Girl Who Decided to Go for It | - | - | - | $19,219 | 227 | $264,626 | Jun 18 | Roadside Attractions | false |
| 27 | The Truffle Hunters | - | - | - | $17,688 | 105 | $521,202 | Mar 5 | Sony Pictures Classics | false |
| 28 | The God Committee | - | - | - | $16,926 | 28 | $32,934 | Jul 2 | Vertical Entertainment | false |
| 29 | Lansky | - | - | - | $16,438 | 49 | $61,030 | Jun 25 | Vertical Entertainment | false |
| 30 | Truman & Tennessee: An Intimate Conversation | - | - | - | $10,202 | 22 | $54,817 | Jun 18 | Kino Lorber | false |
| 31 | First Date | - | - | - | $10,183 | 21 | $15,974 | Jul 2 | Magnolia Pictures | false |
| 32 | Summer of 85 | - | - | - | $10,052 | 23 | $71,788 | Jun 18 | Music Box Films | false |
| 33 | The Swimming Pool 2021 Re-release | - | - | - | $9,598 | 10 | $211,467 | May 14 | Rialto Distribution | false |
| 34 | The Red Circle 2021 Re-release | - | - | - | $7,402 | 5 | $62,850 | Jun 25 | Rialto Pictures | false |
| 35 | The Dry | - | - | - | $6,215 | 186 | $364,237 | May 21 | IFC Films | false |
| 36 | Shiva Baby | - | - | - | $3,629 | 27 | $159,294 | Apr 2 | Utopia | false |
| 37 | The Ladykillers 2021 Re-release | - | - | - | $3,226 | 3 | $23,213 | Jun 4 | Rialto Pictures | false |
| 38 | Undine | - | - | - | $2,510 | 56 | $78,689 | Jun 4 | IFC Films | false |
| 39 | Censor | - | - | - | $2,316 | 93 | $90,050 | Jun 11 | Magnolia Pictures | false |
| 40 | Lydia Lunch: The War Is Never Over | - | - | - | $2,034 | 4 | $12,948 | Jun 30 | Kino Lorber | false |
| 41 | Our Ladies | - | - | - | $1,703 | 25 | $27,558 | Jun 18 | Sony Pictures Releasing | false |
| 42 | About Endlessness | - | - | - | $1,419 | 17 | $51,386 | Apr 30 | Magnolia Pictures | false |
| 43 | Operation Portugal | - | - | - | $888 | 10 | $1,096 | Jul 2 | Sony Pictures Releasing | false |
| 44 | Together Together | - | - | - | $476 | 665 | $1,437,938 | Apr 23 | Bleecker Street Media | false |
| 45 | Holler | - | - | - | $338 | 31 | $28,706 | Jun 11 | IFC Films | false |
| 46 | The Evil Next Door | - | - | - | $248 | 3 | $1,010 | Jun 25 | Magnolia Pictures | false |
