| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Inglourious Basterds | - | - | - | $3,321,096 | 3,358 | $120,540,719 | Aug 21 | The Weinstein Company | false |
| 2 | The Final Destination | - | - | - | $2,926,187 | 3,121 | $66,477,700 | Aug 28 | Warner Bros. | false |
| 3 | All About Steve | - | - | - | $2,816,592 | 2,265 | $33,862,903 | Sep 4 | Twentieth Century Fox | false |
| 4 | Gamer | - | - | - | $2,047,704 | 2,502 | $20,534,907 | Sep 4 | Lionsgate | false |
| 5 | District 9 | - | - | - | $2,037,654 | 3,180 | $115,646,235 | Aug 14 | TriStar Pictures | false |
| 6 | Julie & Julia | - | - | - | $1,752,991 | 2,528 | $94,125,426 | Aug 7 | Sony Pictures Releasing | false |
| 7 | G.I. Joe: The Rise of Cobra | - | - | - | $1,530,175 | 4,007 | $150,201,498 | Aug 7 | Paramount Pictures | false |
| 8 | Extract | - | - | - | $1,173,526 | 1,614 | $10,823,158 | Sep 4 | Miramax | false |
| 9 | The Time Traveler's Wife | - | - | - | $1,139,138 | 2,988 | $63,414,846 | Aug 14 | Warner Bros. | false |
| 10 | Halloween II | - | - | - | $1,127,594 | 3,088 | $33,392,973 | Aug 28 | Dimension Films | false |
| 11 | Shorts | - | - | - | $1,110,779 | 3,105 | $20,919,166 | Aug 21 | Warner Bros. | false |
| 12 | G-Force | - | - | - | $842,825 | 3,697 | $119,436,770 | Jul 24 | Walt Disney Studios Motion Pictures | false |
| 13 | Harry Potter and the Half-Blood Prince | - | - | - | $674,108 | 4,455 | $301,959,197 | Jul 15 | Warner Bros. | false |
| 14 | Ponyo | - | - | - | $561,090 | 927 | $15,090,399 | Aug 14 | Walt Disney Studios Motion Pictures | false |
| 15 | 500 Days of Summer | - | - | - | $530,892 | 1,048 | $32,391,374 | Jul 17 | Fox Searchlight Pictures | false |
| 16 | Taking Woodstock | - | - | - | $433,268 | 1,395 | $7,460,204 | Aug 26 | Focus Features | false |
| 17 | The Hangover | - | - | - | $275,861 | 3,545 | $277,322,503 | Jun 5 | Warner Bros. | false |
| 18 | Up | - | - | - | $235,481 | 3,886 | $293,004,164 | May 29 | Walt Disney Studios Motion Pictures | false |
| 19 | The Ugly Truth | - | - | - | $209,211 | 2,975 | $88,915,214 | Jul 24 | Sony Pictures Releasing | false |
| 20 | Transformers: Revenge of the Fallen | - | - | - | $206,695 | 4,293 | $402,111,870 | Jun 24 | DreamWorks | false |
| 21 | Ice Age: Dawn of the Dinosaurs | - | - | - | $187,232 | 4,102 | $196,573,705 | Jul 1 | Twentieth Century Fox | false |
| 22 | The Proposal | - | - | - | $159,176 | 3,158 | $163,958,031 | Jun 19 | Walt Disney Studios Motion Pictures | false |
| 23 | Aliens in the Attic | - | - | - | $154,097 | 3,108 | $25,200,412 | Jul 31 | Twentieth Century Fox | false |
| 24 | My One and Only | - | - | - | $117,882 | 256 | $2,479,538 | Aug 21 | Freestyle Releasing | false |
| 25 | The Goods: Live Hard, Sell Hard | - | - | - | $92,335 | 1,849 | $15,122,676 | Aug 14 | Paramount Vantage | false |
| 26 | Under the Sea 3D | - | - | - | $88,832 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 27 | Star Trek | - | - | - | $76,857 | 4,053 | $257,730,019 | May 8 | Paramount Pictures | false |
| 28 | The Hurt Locker | - | - | - | $71,263 | 535 | $17,017,811 | Jun 26 | Summit Entertainment | false |
| 29 | Adam | - | - | - | $69,623 | 177 | $2,277,396 | Jul 29 | Fox Searchlight Pictures | false |
| 30 | Post Grad | - | - | - | $67,834 | 1,959 | $6,380,019 | Aug 21 | Twentieth Century Fox | false |
| 31 | Night at the Museum: Battle of the Smithsonian | - | - | - | $61,505 | 4,101 | $177,243,721 | May 22 | Twentieth Century Fox | false |
| 32 | My Sister's Keeper | - | - | - | $53,113 | 2,606 | $49,200,230 | Jun 26 | Warner Bros. | false |
| 33 | The September Issue | - | - | - | $48,845 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 34 | Funny People | - | - | - | $42,840 | 3,008 | $51,855,045 | Jul 31 | Universal Pictures | false |
| 35 | A Perfect Getaway | - | - | - | $39,105 | 2,159 | $15,515,460 | Aug 7 | Universal Pictures | false |
| 36 | Orphan | - | - | - | $37,376 | 2,750 | $41,596,251 | Jul 24 | Warner Bros. | false |
| 37 | Bandslam | - | - | - | $29,746 | 2,121 | $5,210,988 | Aug 14 | Summit Entertainment | false |
| 38 | Paper Heart | - | - | - | $19,462 | 96 | $1,274,062 | Aug 7 | Overture Films | false |
| 39 | Carriers | - | - | - | $19,126 | 100 | $104,352 | Sep 4 | Paramount Vantage | false |
| 40 | Kaminey | - | - | - | $11,723 | 85 | $1,291,827 | Aug 14 | UTV Motion Pictures | false |
| 41 | The Cove | - | - | - | $10,859 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 42 | The Collector | - | - | - | $9,551 | 1,325 | $7,712,114 | Jul 31 | Freestyle Releasing | false |
| 43 | Terminator Salvation | - | - | - | $3,046 | 3,602 | $125,322,469 | May 21 | Warner Bros. | false |
| 44 | I Love You, Beth Cooper | - | - | - | $2,445 | 1,872 | $14,800,725 | Jul 10 | Twentieth Century Fox | false |
| 45 | American Casino | - | - | - | $2,186 | 3 | $50,437 | Aug 14 | Argot Pictures | false |
| 46 | Shrink | - | - | - | $1,237 | 27 | $189,621 | Jul 24 | Roadside Attractions | false |
| 47 | The Boys | - | - | - | $898 | 5 | $55,513 | May 22 | Walt Disney Studios Motion Pictures | false |
| 48 | The Stoning of Soraya M. | - | - | - | $698 | 34 | $637,421 | Jun 26 | Roadside Attractions | false |
| 49 | The Open Road | - | - | - | $628 | 14 | $19,716 | Aug 28 | Anchor Bay Films | false |
| 50 | Spread | - | - | - | $590 | 103 | $250,618 | Aug 14 | Anchor Bay Films | false |
| 51 | Mystery Team | - | - | - | $500 | 4 | $89,442 | Aug 28 | Roadside Attractions | false |
| 52 | Z | - | - | - | $316 | 2 | $83,305 | Mar 13 | Rialto Pictures | false |
| 53 | Alien Trespass | - | - | - | $122 | 40 | $104,526 | Apr 3 | Roadside Attractions | false |
| 54 | Battle for Terra | - | - | - | $122 | 1,159 | $1,647,083 | May 1 | Lionsgate | false |
| 55 | Goodbye Solo | - | - | - | $56 | 34 | $870,781 | Mar 27 | Roadside Attractions | false |
