| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $126,917,373 | 4,264 | $317,101,119 | May 22 | Paramount Pictures | false |
| 2 | The Chronicles of Narnia: Prince Caspian | - | - | - | $29,810,163 | 3,929 | $141,621,490 | May 16 | Walt Disney Studios Motion Pictures | false |
| 3 | Iron Man | - | - | - | $26,111,130 | 4,154 | $318,604,126 | May 2 | Paramount Pictures | false |
| 4 | What Happens in Vegas | - | - | - | $11,363,713 | 3,255 | $80,277,646 | May 9 | Twentieth Century Fox | false |
| 5 | Speed Racer | - | - | - | $5,272,202 | 3,606 | $43,945,766 | May 9 | Warner Bros. | false |
| 6 | Made of Honor | - | - | - | $4,240,435 | 2,816 | $46,012,734 | May 2 | Sony Pictures Releasing | false |
| 7 | Baby Mama | - | - | - | $4,208,105 | 2,627 | $60,494,212 | Apr 25 | Universal Pictures | false |
| 8 | Forgetting Sarah Marshall | - | - | - | $2,269,775 | 2,872 | $63,172,463 | Apr 18 | Universal Pictures | false |
| 9 | Harold & Kumar Escape from Guantanamo Bay | - | - | - | $1,163,460 | 2,545 | $38,108,728 | Apr 25 | Warner Bros. | false |
| 10 | The Visitor | - | - | - | $940,037 | 270 | $9,427,089 | Apr 11 | Overture Films | false |
| 11 | Horton Hears a Who! | - | - | - | $625,105 | 3,961 | $154,529,439 | Mar 14 | Twentieth Century Fox | false |
| 12 | The Forbidden Kingdom | - | - | - | $556,015 | 3,151 | $52,075,270 | Apr 18 | Lionsgate | false |
| 13 | Then She Found Me | - | - | - | $503,004 | 153 | $3,735,717 | Apr 25 | THINKFilm | false |
| 14 | Young@Heart | - | - | - | $425,820 | 212 | $3,992,189 | Apr 9 | Fox Searchlight Pictures | false |
| 15 | Nim's Island | - | - | - | $397,290 | 3,518 | $48,006,762 | Apr 4 | Twentieth Century Fox | false |
| 16 | College Road Trip | - | - | - | $360,438 | 2,706 | $45,610,425 | Mar 7 | Walt Disney Studios Motion Pictures | false |
| 17 | Drillbit Taylor | - | - | - | $346,197 | 3,061 | $32,862,104 | Mar 21 | Paramount Pictures | false |
| 18 | Son of Rambow | - | - | - | $323,617 | 155 | $1,785,505 | May 2 | Paramount Vantage | false |
| 19 | Prom Night | - | - | - | $253,294 | 2,821 | $43,869,350 | Apr 11 | Screen Gems | false |
| 20 | Roman de gare | - | - | - | $201,142 | 38 | $1,852,764 | Apr 25 | The Samuel Goldwyn Company | false |
| 21 | Sea Monsters: A Prehistoric Adventure | - | - | - | $181,517 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 22 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $139,964 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 23 | Before the Rains | - | - | - | $139,382 | 44 | $1,029,655 | May 9 | Roadside Attractions | false |
| 24 | 10,000 BC | - | - | - | $132,053 | 3,454 | $94,784,201 | Mar 7 | Warner Bros. | false |
| 25 | The Counterfeiters | - | - | - | $129,548 | 170 | $5,488,570 | Feb 22 | Sony Pictures Classics | false |
| 26 | Street Kings | - | - | - | $122,740 | 2,469 | $26,418,667 | Apr 11 | Fox Searchlight Pictures | false |
| 27 | National Treasure: Book of Secrets | - | - | - | $111,242 | 3,832 | $219,964,115 | Dec 21 | Walt Disney Studios Motion Pictures | false |
| 28 | Leatherheads | - | - | - | $110,115 | 2,798 | $31,373,938 | Apr 4 | Universal Pictures | false |
| 29 | Superhero Movie | - | - | - | $108,747 | 2,965 | $25,881,068 | Mar 28 | Metro-Goldwyn-Mayer (MGM) | false |
| 30 | Reprise | - | - | - | $107,885 | 15 | $554,826 | May 16 | Miramax | false |
| 31 | The Ruins | - | - | - | $97,135 | 2,814 | $17,432,844 | Apr 4 | DreamWorks | false |
| 32 | Priceless | - | - | - | $92,093 | 44 | $2,165,188 | Mar 30 | The Samuel Goldwyn Company | false |
| 33 | U2 3D | - | - | - | $88,481 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 34 | Jumper | - | - | - | $87,143 | 3,430 | $80,172,128 | Feb 14 | Twentieth Century Fox | false |
| 35 | Shine a Light | - | - | - | $79,510 | 277 | $5,505,267 | Apr 4 | Paramount Vantage | false |
| 36 | Redbelt | - | - | - | $75,342 | 1,379 | $2,345,941 | May 2 | Sony Pictures Classics | false |
| 37 | The Fall | - | - | - | $67,759 | 111 | $2,266,905 | May 9 | Roadside Attractions | false |
| 38 | The Bank Job | - | - | - | $66,085 | 1,613 | $30,060,660 | Mar 7 | Lionsgate | false |
| 39 | Smart People | - | - | - | $65,266 | 1,119 | $9,511,289 | Apr 11 | Miramax | false |
| 40 | Magnificent Desolation: Walking on the Moon | - | - | - | $64,150 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 41 | The Bucket List | - | - | - | $56,379 | 2,915 | $93,466,502 | Dec 25 | Warner Bros. | false |
| 42 | The Children of Huang Shi | - | - | - | $55,760 | 43 | $1,031,872 | May 23 | Sony Pictures Classics | false |
| 43 | My Blueberry Nights | - | - | - | $48,825 | 69 | $867,275 | Apr 4 | The Weinstein Company | false |
| 44 | Under the Same Moon | - | - | - | $48,557 | 454 | $12,590,147 | Mar 19 | The Weinstein Company | false |
| 45 | Deep Sea | - | - | - | $48,144 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 46 | Expelled: No Intelligence Allowed | - | - | - | $46,314 | 1,052 | $7,720,487 | Apr 18 | Rocky Mountain Pictures | false |
| 47 | War, Inc. | - | - | - | $45,714 | 33 | $580,862 | May 23 | First Look International | false |
| 48 | Flawless | - | - | - | $41,587 | 65 | $1,200,234 | Mar 28 | Magnolia Pictures | false |
| 49 | Fugitive Pieces | - | - | - | $40,310 | 38 | $635,783 | May 2 | The Samuel Goldwyn Company | false |
| 50 | OSS 117: Cairo, Nest of Spies | - | - | - | $38,220 | 13 | $303,543 | May 9 | Music Box Films | false |
| 51 | Space Station 3D | - | - | - | $36,909 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 52 | Fool's Gold | - | - | - | $33,154 | 3,125 | $70,231,041 | Feb 8 | Warner Bros. | false |
| 53 | In Bruges | - | - | - | $32,182 | 232 | $7,800,824 | Feb 8 | Focus Features | false |
| 54 | The Band's Visit | - | - | - | $32,086 | 121 | $3,054,457 | Feb 8 | Sony Pictures Classics | false |
| 55 | Roving Mars | - | - | - | $30,530 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 56 | Surfwise | - | - | - | $27,974 | 13 | $269,994 | May 9 | Magnolia Pictures | false |
| 57 | My Father My Lord | - | - | - | $26,740 | 9 | $203,708 | May 16 | Kino International | false |
| 58 | Standard Operating Procedure | - | - | - | $26,267 | 21 | $229,117 | Apr 25 | Sony Pictures Classics | false |
| 59 | Jellyfish | - | - | - | $22,598 | 14 | $341,221 | Apr 4 | Zeitgeist Films | false |
| 60 | Up the Yangtze | - | - | - | $22,549 | 23 | $783,969 | Apr 25 | Zeitgeist Films | false |
| 61 | The Life Before Her Eyes | - | - | - | $21,246 | 48 | $303,439 | Apr 18 | Magnolia Pictures | false |
| 62 | Mister Lonely | - | - | - | $19,647 | 8 | $167,396 | May 2 | IFC Films | false |
| 63 | Shutter | - | - | - | $19,073 | 2,756 | $25,928,550 | Mar 21 | Twentieth Century Fox | false |
| 64 | The Edge of Heaven | - | - | - | $18,593 | 20 | $742,349 | May 21 | Strand Releasing | false |
| 65 | Flight of the Red Balloon | - | - | - | $18,476 | 14 | $461,674 | Apr 4 | IFC Films | false |
| 66 | Galapagos | - | - | - | $15,849 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 67 | Deception | - | - | - | $15,463 | 2,001 | $4,598,506 | Apr 25 | Twentieth Century Fox | false |
| 68 | Blood of My Blood | - | - | - | $14,037 | 7 | $55,730 | May 14 | IFC Films | false |
| 69 | Where in the World Is Osama Bin Laden? | - | - | - | $13,928 | 102 | $384,955 | Apr 18 | The Weinstein Company | false |
| 70 | Refusenik | - | - | - | $13,705 | 3 | $39,456 | Apr 11 | Abramorama | false |
| 71 | A Jihad for Love | - | - | - | $13,418 | 5 | $105,651 | May 21 | First Run | false |
| 72 | Alvin and the Chipmunks | - | - | - | $10,884 | 3,499 | $217,326,974 | Dec 14 | Twentieth Century Fox | false |
| 73 | Bloodline | - | - | - | $9,091 | 5 | $64,698 | May 9 | Cinema Libre Studio | false |
| 74 | A Four Letter Word | - | - | - | $8,547 | 5 | $72,568 | Mar 28 | Embrem Entertainment | false |
| 75 | Wild Safari - A South African Adventure | - | - | - | $7,932 | 21 | $16,621,530 | Apr 8 | nWave Pictures | false |
| 76 | America the Beautiful | - | - | - | $7,663 | 5 | $76,173 | May 9 | First Independent Pictures | false |
| 77 | Constantine's Sword | - | - | - | $7,633 | 6 | $179,507 | Apr 18 | First Run | false |
| 78 | Juno | - | - | - | $6,672 | 2,534 | $143,495,265 | Dec 5 | Fox Searchlight Pictures | false |
| 79 | Bra Boys | - | - | - | $6,590 | 23 | $155,056 | Apr 11 | Slowhand Cinema Releasing | false |
| 80 | 27 Dresses | - | - | - | $6,445 | 3,074 | $76,808,654 | Jan 18 | Twentieth Century Fox | false |
| 81 | My Brother is an Only Child | - | - | - | $6,215 | 14 | $255,620 | Mar 28 | THINKFilm | false |
| 82 | The Singing Revolution | - | - | - | $5,974 | 5 | $426,855 | Dec 7 | Abramorama | false |
| 83 | Caramel | - | - | - | $4,973 | 50 | $1,055,580 | Feb 1 | Roadside Attractions | false |
| 84 | The Year My Parents Went on Vacation | - | - | - | $4,909 | 30 | $807,117 | Feb 15 | City Lights Pictures | false |
| 85 | Married Life | - | - | - | $4,858 | 120 | $1,507,990 | Mar 7 | Sony Pictures Classics | false |
| 86 | Il trittico dell'amore | - | - | - | $4,057 | 43 | $80,374 | May 2 | Emerging Pictures | false |
| 87 | Paranoid Park | - | - | - | $4,025 | 37 | $486,767 | Mar 7 | IFC Films | false |
| 88 | A Man Named Pearl | - | - | - | $3,803 | 9 | $208,392 | Aug 31 | Tentmakers Entertainment | false |
| 89 | The Dhamma Brothers | - | - | - | $3,631 | 3 | $40,492 | Apr 11 | Balcony Releasing | false |
| 90 | Love Songs | - | - | - | $3,230 | 7 | $104,567 | Mar 21 | IFC Films | false |
| 91 | Tuya's Marriage | - | - | - | $3,052 | 5 | $88,148 | Apr 4 | Music Box Films | false |
| 92 | La Rondine | - | - | - | $2,972 | 5 | $49,088 | May 19 | Emerging Pictures | false |
| 93 | Girls Rock! | - | - | - | $2,796 | 14 | $159,294 | Mar 7 | Shadow Distribution | false |
| 94 | Heavy Metal in Baghdad | - | - | - | $2,539 | 2 | $4,070 | May 23 | Hart Sharp Entertainment | false |
| 95 | The Duchess of Langeais | - | - | - | $2,523 | 11 | $282,749 | Feb 22 | IFC Films | false |
| 96 | Snow Angels | - | - | - | $2,348 | 47 | $402,858 | Mar 7 | Warner Independent Pictures (WIP) | false |
| 97 | Noise | - | - | - | $2,328 | 2 | $16,513 | May 9 | THINKFilm | false |
| 98 | As It Is in Heaven 2008 Re-release | - | - | - | $2,226 | 1 | $10,236 | May 2 | Vitagraph Films | false |
| 99 | Yella | - | - | - | $2,043 | 2 | $30,647 | May 16 | The Cinema Guild | false |
| 100 | Stop-Loss | - | - | - | $1,628 | 1,305 | $10,915,744 | Mar 28 | Paramount Pictures | false |
| 101 | Chicago 10 | - | - | - | $1,627 | 14 | $177,490 | Feb 29 | Roadside Attractions | false |
| 102 | Box Elder | - | - | - | $1,600 | 2 | $48,996 | Mar 3 | - | false |
| 103 | Bella | - | - | - | $1,481 | 457 | $8,070,537 | Oct 26 | Roadside Attractions | false |
| 104 | Last Year at Marienbad | - | - | - | $1,463 | 2 | $144,492 | Jan 18 | Rialto Pictures | false |
| 105 | Starting Out in the Evening | - | - | - | $1,319 | 43 | $898,786 | Nov 23 | Roadside Attractions | false |
| 106 | Water Lilies | - | - | - | $1,050 | 3 | $85,440 | Apr 4 | Koch Lorber Films | false |
| 107 | T-Rex: Back to the Cretaceous | - | - | - | $1,007 | 38 | $53,354,743 | Oct 23 | IMAX | false |
| 108 | Chop Shop | - | - | - | $958 | 3 | $125,045 | Feb 27 | Koch Lorber Films | false |
| 109 | Honeydripper | - | - | - | $913 | 26 | $267,880 | Dec 28 | Emerging Pictures | false |
| 110 | Alexandra | - | - | - | $737 | 4 | $128,222 | Mar 26 | The Cinema Guild | false |
| 111 | Planet B-Boy | - | - | - | $734 | 14 | $273,870 | Mar 21 | Elephant Eye Films | false |
| 112 | Bab'Aziz: The Prince That Contemplated His Soul | - | - | - | $731 | 2 | $89,672 | Feb 8 | Typecast Releasing | false |
| 113 | La Traviata | - | - | - | $570 | 49 | $195,494 | Feb 15 | Emerging Pictures | false |
| 114 | Battle for Haditha | - | - | - | $329 | 2 | $10,310 | May 7 | Lafayette Films | false |
| 115 | Irina Palm | - | - | - | $265 | 4 | $44,383 | Mar 21 | Strand Releasing | false |
| 116 | Taxi to the Dark Side | - | - | - | $153 | 20 | $274,661 | Jan 18 | THINKFilm | false |
| 117 | Kiss the Bride | - | - | - | $129 | 5 | $32,033 | Apr 18 | Regent Releasing | false |
| 118 | Shotgun Stories | - | - | - | $81 | 4 | $46,026 | Dec 14 | International Film Circuit | false |
