| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Four Christmases | - | - | - | $8,902,878 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 2 | Twilight | - | - | - | $5,231,976 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 3 | Quantum of Solace | - | - | - | $4,586,803 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 4 | Bolt | - | - | - | $4,322,338 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 5 | Australia | - | - | - | $2,935,175 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 6 | Transporter 3 | - | - | - | $2,842,544 | 2,626 | $31,715,062 | Nov 26 | Lionsgate | false |
| 7 | Madagascar: Escape 2 Africa | - | - | - | $2,210,364 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 8 | Role Models | - | - | - | $1,327,975 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 9 | The Boy in the Striped Pajamas | - | - | - | $252,637 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 10 | Slumdog Millionaire | - | - | - | $220,236 | 2,943 | $141,319,928 | Nov 12 | Fox Searchlight Pictures | false |
| 11 | Milk | - | - | - | $219,141 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 12 | Changeling | - | - | - | $212,100 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 13 | High School Musical 3: Senior Year | - | - | - | $127,369 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 14 | Zack and Miri Make a Porno | - | - | - | $113,858 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 15 | Soul Men | - | - | - | $91,125 | 2,048 | $12,082,391 | Nov 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 16 | The Secret Life of Bees | - | - | - | $88,242 | 1,630 | $37,770,162 | Oct 17 | Fox Searchlight Pictures | false |
| 17 | Fireproof | - | - | - | $76,845 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 18 | The Dark Knight | - | - | - | $63,021 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 19 | Eagle Eye | - | - | - | $49,607 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 20 | Happy-Go-Lucky | - | - | - | $38,986 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 21 | Saw V | - | - | - | $25,744 | 3,084 | $56,746,769 | Oct 24 | Lionsgate | false |
| 22 | Righteous Kill | - | - | - | $24,741 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 23 | Body of Lies | - | - | - | $15,450 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 24 | Burn After Reading | - | - | - | $13,595 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 25 | Max Payne | - | - | - | $13,148 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 26 | The Haunting of Molly Hartley | - | - | - | $12,444 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 27 | Appaloosa | - | - | - | $12,347 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 28 | Igor | - | - | - | $11,587 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 29 | Religulous | - | - | - | $9,996 | 568 | $13,011,160 | Oct 1 | Lionsgate | false |
| 30 | W. | - | - | - | $8,906 | 2,050 | $25,534,493 | Oct 17 | Lionsgate | false |
| 31 | The Polar Express 2008 IMAX Release | - | - | - | $7,672 | 26 | $1,705,694 | Nov 21 | Warner Bros. | false |
| 32 | Deep Sea | - | - | - | $7,659 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 33 | City of Ember | - | - | - | $7,638 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 34 | The Duchess | - | - | - | $6,887 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 35 | RocknRolla | - | - | - | $6,197 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 36 | Nights in Rodanthe | - | - | - | $5,426 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 37 | Vicky Cristina Barcelona | - | - | - | $5,106 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 38 | Pride and Glory | - | - | - | $2,991 | 2,585 | $15,740,721 | Oct 24 | Warner Bros. | false |
| 39 | Journey to the Center of the Earth | - | - | - | $2,792 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 40 | Sex Drive | - | - | - | $2,593 | 2,421 | $8,402,485 | Oct 17 | Summit Entertainment | false |
| 41 | Noah's Arc: Jumping the Broom | - | - | - | $2,133 | 9 | $532,878 | Oct 24 | Logo | false |
| 42 | Repo! The Genetic Opera | - | - | - | $1,214 | 11 | $146,750 | Nov 7 | Lionsgate | false |
| 43 | Were the World Mine | - | - | - | $1,169 | 4 | $123,789 | Oct 31 | SPEAK Productions | false |
| 44 | How to Lose Friends & Alienate People | - | - | - | $938 | 1,750 | $2,778,752 | Oct 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 45 | Lola Montès | - | - | - | $434 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
| 46 | House | - | - | - | $229 | 363 | $575,048 | Nov 7 | Roadside Attractions | false |
| 47 | Eden | - | - | - | $217 | 3 | $15,611 | Nov 14 | Liberation Entertainment | false |
| 48 | The First Basket | - | - | - | $185 | 4 | $20,440 | Oct 29 | Laemmle/Zeller Films | false |
| 49 | I.O.U.S.A. | - | - | - | $151 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 50 | The Alphabet Killer | - | - | - | $112 | 2 | $29,784 | Nov 7 | Anchor Bay Films | false |
| 51 | The Other End of the Line | - | - | - | $111 | 91 | $115,592 | Oct 31 | Metro-Goldwyn-Mayer (MGM) | false |
