| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Happy Feet | - | - | - | $50,645,518 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 2 | Casino Royale | - | - | - | $44,881,148 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 3 | Deja Vu | - | - | - | $28,649,398 | 3,108 | $64,038,616 | Nov 22 | Walt Disney Studios Motion Pictures | false |
| 4 | Deck the Halls | - | - | - | $16,916,923 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 5 | Borat | - | - | - | $15,265,811 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 6 | The Santa Clause 3: The Escape Clause | - | - | - | $13,717,450 | 3,458 | $84,500,122 | Nov 3 | Walt Disney Studios Motion Pictures | false |
| 7 | Stranger Than Fiction | - | - | - | $8,143,756 | 2,270 | $40,660,952 | Nov 10 | Sony Pictures Releasing | false |
| 8 | Flushed Away | - | - | - | $7,570,134 | 3,707 | $64,665,672 | Nov 3 | DreamWorks | false |
| 9 | Bobby | - | - | - | $6,019,593 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 10 | The Fountain | - | - | - | $5,456,908 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 11 | Tenacious D in the Pick of Destiny | - | - | - | $5,212,156 | 1,919 | $8,334,575 | Nov 22 | New Line Cinema | true |
| 12 | The Queen | - | - | - | $3,280,016 | 1,850 | $56,441,711 | Sep 30 | Miramax | true |
| 13 | Babel | - | - | - | $2,594,123 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 14 | For Your Consideration | - | - | - | $2,576,406 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 15 | Saw III | - | - | - | $2,365,005 | 3,167 | $80,238,724 | Oct 27 | Lionsgate | false |
| 16 | The Departed | - | - | - | $2,336,729 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 17 | Let's Go to Prison | - | - | - | $1,428,385 | 1,495 | $4,630,045 | Nov 17 | Universal Pictures | false |
| 18 | Dhoom 2 | - | - | - | $1,298,477 | 63 | $2,643,586 | Nov 23 | Yash Raj Films | false |
| 19 | The Prestige | - | - | - | $1,272,404 | 2,305 | $53,089,891 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 20 | Flags of Our Fathers | - | - | - | $426,424 | 2,375 | $33,602,376 | Oct 20 | DreamWorks | false |
| 21 | A Good Year | - | - | - | $421,937 | 2,067 | $7,459,300 | Nov 10 | Twentieth Century Fox | false |
| 22 | Fast Food Nation | - | - | - | $275,523 | 321 | $1,005,539 | Nov 17 | Fox Searchlight Pictures | false |
| 23 | The Polar Express 2006 IMAX Release | - | - | - | $273,270 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 24 | Flicka | - | - | - | $214,273 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 25 | Marie Antoinette | - | - | - | $205,142 | 870 | $15,962,471 | Oct 20 | Sony Pictures Releasing | false |
| 26 | The Illusionist | - | - | - | $175,309 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 27 | Open Season | - | - | - | $169,254 | 3,833 | $85,105,259 | Sep 29 | Sony Pictures Releasing | false |
| 28 | Deep Sea | - | - | - | $168,198 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 29 | The Wedding Weekend | - | - | - | $166,340 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 30 | Little Miss Sunshine | - | - | - | $156,038 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 31 | Man of the Year | - | - | - | $141,040 | 2,626 | $37,327,390 | Oct 13 | Universal Pictures | false |
| 32 | The Marine | - | - | - | $136,028 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 33 | The History Boys | - | - | - | $132,639 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 34 | The Return | - | - | - | $126,217 | 1,986 | $7,749,851 | Nov 10 | Rogue Pictures | false |
| 35 | Jackass Number Two | - | - | - | $97,962 | 3,063 | $72,778,712 | Sep 22 | Paramount Pictures | false |
| 36 | School for Scoundrels | - | - | - | $92,017 | 3,007 | $17,807,569 | Sep 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 37 | The Last King of Scotland | - | - | - | $87,625 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 38 | Harsh Times | - | - | - | $73,583 | 956 | $3,337,931 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | Employee of the Month | - | - | - | $47,036 | 2,579 | $28,444,855 | Oct 6 | Lionsgate | false |
| 40 | Fur: An Imaginary Portrait of Diane Arbus | - | - | - | $46,554 | 39 | $223,202 | Nov 10 | Picturehouse | false |
| 41 | Copying Beethoven | - | - | - | $42,348 | 29 | $384,029 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 42 | The Science of Sleep | - | - | - | $23,439 | 243 | $4,670,644 | Sep 22 | Warner Independent Pictures (WIP) | false |
| 43 | Everyone's Hero | - | - | - | $14,135 | 2,898 | $14,523,101 | Sep 15 | Twentieth Century Fox | false |
| 44 | The Devil Wears Prada | - | - | - | $13,227 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 45 | The U.S. vs. John Lennon | - | - | - | $11,806 | 65 | $1,109,146 | Sep 15 | Lionsgate | false |
| 46 | Deliver Us from Evil | - | - | - | $10,574 | 24 | $201,275 | Oct 13 | Lionsgate | false |
| 47 | Who the #$&% Is Jackson Pollock? | - | - | - | $3,256 | 2 | $13,710 | Nov 15 | Picturehouse | false |
| 48 | Hannari: Geisha Modern | - | - | - | $3,128 | 1 | $14,974 | Nov 17 | Sakura Productions USA | false |
| 49 | Infamous | - | - | - | $3,007 | 179 | $1,151,330 | Oct 13 | Warner Independent Pictures (WIP) | false |
| 50 | Flyboys | - | - | - | $1,209 | 2,033 | $13,090,630 | Sep 22 | Metro-Goldwyn-Mayer (MGM) | false |
