| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: New Moon | - | - | - | $66,273,378 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 2 | The Blind Side | - | - | - | $57,519,188 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 3 | 2012 | - | - | - | $25,224,935 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 4 | Old Dogs | - | - | - | $24,228,546 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 5 | A Christmas Carol | - | - | - | $22,112,447 | 3,683 | $137,855,863 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 6 | Ninja Assassin | - | - | - | $21,193,565 | 2,503 | $38,122,883 | Nov 25 | Warner Bros. | false |
| 7 | Planet 51 | - | - | - | $13,900,383 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 8 | Fantastic Mr. Fox | - | - | - | $9,415,757 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 9 | Precious | - | - | - | $9,392,227 | 1,003 | $47,566,524 | Nov 6 | Lionsgate | false |
| 10 | The Men Who Stare at Goats | - | - | - | $2,157,602 | 2,453 | $32,428,195 | Nov 6 | Overture Films | false |
| 11 | The Road | - | - | - | $1,977,453 | 396 | $8,117,000 | Nov 25 | Dimension Films | false |
| 12 | The Boondock Saints II: All Saints Day | - | - | - | $1,946,776 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 13 | The Boat That Rocked | - | - | - | $1,330,797 | 883 | $8,017,917 | Nov 13 | Focus Features | false |
| 14 | Couples Retreat | - | - | - | $1,314,415 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 15 | The Princess and the Frog | - | - | - | $1,216,860 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 16 | This Is It | - | - | - | $1,142,023 | 3,481 | $72,091,016 | Oct 28 | Sony Pictures Releasing | false |
| 17 | Law Abiding Citizen | - | - | - | $1,092,449 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 18 | The Fourth Kind | - | - | - | $850,525 | 2,530 | $25,486,040 | Nov 6 | Universal Pictures | false |
| 19 | Paranormal Activity | - | - | - | $705,517 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 20 | A Serious Man | - | - | - | $600,703 | 262 | $9,228,768 | Oct 2 | Focus Features | false |
| 21 | Where the Wild Things Are | - | - | - | $526,431 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 22 | Zombieland | - | - | - | $334,732 | 3,171 | $75,590,286 | Oct 2 | Sony Pictures Releasing | false |
| 23 | Kurbaan | - | - | - | $221,143 | 83 | $754,268 | Nov 20 | UTV Motion Pictures | false |
| 24 | Cloudy with a Chance of Meatballs | - | - | - | $220,955 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 25 | Astro Boy | - | - | - | $217,310 | 3,020 | $19,551,067 | Oct 23 | Summit Entertainment | false |
| 26 | Julie & Julia | - | - | - | $180,342 | 2,528 | $94,125,426 | Aug 7 | Sony Pictures Releasing | false |
| 27 | Amelia | - | - | - | $159,441 | 1,070 | $14,246,488 | Oct 23 | Fox Searchlight Pictures | false |
| 28 | The Box | - | - | - | $133,603 | 2,635 | $15,051,977 | Nov 6 | Warner Bros. | false |
| 29 | Under the Sea 3D | - | - | - | $106,344 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 30 | The Invention of Lying | - | - | - | $93,503 | 1,743 | $18,451,251 | Oct 2 | Warner Bros. | false |
| 31 | Me and Orson Welles | - | - | - | $85,422 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 32 | Inglourious Basterds | - | - | - | $78,986 | 3,358 | $120,540,719 | Aug 21 | The Weinstein Company | false |
| 33 | The Hangover | - | - | - | $70,491 | 3,545 | $277,322,503 | Jun 5 | Warner Bros. | false |
| 34 | Shorts | - | - | - | $62,129 | 3,105 | $20,919,166 | Aug 21 | Warner Bros. | false |
| 35 | The Polar Express 2009 IMAX Release | - | - | - | $58,845 | 21 | $514,354 | Nov 6 | Warner Bros. | false |
| 36 | Fame | - | - | - | $57,473 | 3,133 | $22,455,510 | Sep 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 37 | The Informant! | - | - | - | $50,601 | 2,505 | $33,316,821 | Sep 18 | Warner Bros. | false |
| 38 | Harry Potter and the Half-Blood Prince | - | - | - | $46,411 | 4,455 | $301,959,197 | Jul 15 | Warner Bros. | false |
| 39 | The Maid | - | - | - | $40,738 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 40 | 9 | - | - | - | $39,172 | 2,060 | $31,749,894 | Sep 9 | Focus Features | false |
| 41 | Good Hair | - | - | - | $35,311 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 42 | New York, I Love You | - | - | - | $34,958 | 118 | $1,588,015 | Oct 16 | Vivendi Entertainment | false |
| 43 | Capitalism: A Love Story | - | - | - | $34,780 | 995 | $14,363,397 | Sep 23 | Overture Films | false |
| 44 | All About Steve | - | - | - | $31,004 | 2,265 | $33,862,903 | Sep 4 | Twentieth Century Fox | false |
| 45 | Bright Star | - | - | - | $23,499 | 380 | $4,444,637 | Sep 16 | Apparition | false |
| 46 | The September Issue | - | - | - | $18,299 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 47 | Whip It | - | - | - | $16,517 | 1,738 | $13,043,363 | Oct 2 | Fox Searchlight Pictures | false |
| 48 | The Time Traveler's Wife | - | - | - | $15,728 | 2,988 | $63,414,846 | Aug 14 | Warner Bros. | false |
| 49 | Cirque du Freak: The Vampire's Assistant | - | - | - | $13,175 | 2,754 | $13,869,515 | Oct 23 | Universal Pictures | false |
| 50 | That Evening Sun | - | - | - | $12,933 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 51 | Oh My God | - | - | - | $9,288 | 7 | $38,244 | Nov 13 | Mitropoulos Films | false |
| 52 | Small Change | - | - | - | $6,885 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 53 | The Final Destination | - | - | - | $6,483 | 3,121 | $66,477,700 | Aug 28 | Warner Bros. | false |
| 54 | Gentlemen Broncos | - | - | - | $3,765 | 18 | $113,682 | Oct 30 | Fox Searchlight Pictures | false |
| 55 | The Cove | - | - | - | $1,867 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
