| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Scary Movie 4 | - | - | - | $9,344,901 | 409 | $11,037,123 | Apr 14 | Buena Vista International | false |
| 2 | Inside Man | - | - | - | $9,276,340 | 356 | $14,406,413 | Mar 24 | United International Pictures | false |
| 3 | She's the Man | - | - | - | $7,313,322 | 306 | $8,673,300 | Apr 7 | Entertainment Film Distributors | false |
| 4 | Failure to Launch | - | - | - | $5,361,134 | 353 | $5,540,067 | Mar 31 | United International Pictures | false |
| 5 | The Shaggy Dog | - | - | - | $4,938,135 | 430 | $5,534,468 | Mar 31 | Buena Vista International | false |
| 6 | Hostel | - | - | - | $4,187,180 | 304 | $7,736,178 | Mar 24 | Sony Pictures Releasing | false |
| 7 | Silent Hill | - | - | - | $3,992,336 | 308 | $6,734,879 | Apr 21 | Pathé | false |
| 8 | The Pink Panther | - | - | - | $3,945,495 | 406 | $10,577,372 | Mar 17 | 20th Century Fox International | false |
| 9 | Alien Autopsy | - | - | - | $3,918,998 | 417 | $4,009,720 | Apr 7 | Warner Bros. | false |
| 10 | Take the Lead | - | - | - | $3,599,761 | 301 | $4,240,032 | Apr 7 | Entertainment Film Distributors | false |
| 11 | An American Haunting | - | - | - | $2,947,127 | 269 | $3,394,905 | Apr 14 | Lionsgate | false |
| 12 | American Dreamz | - | - | - | $2,763,231 | 356 | $4,134,874 | Apr 21 | United International Pictures | false |
| 13 | Yours, Mine & Ours | - | - | - | $2,296,917 | 265 | $2,369,263 | Mar 31 | Sony Pictures Releasing | false |
| 14 | Firewall | - | - | - | $2,234,517 | 281 | $2,234,517 | Mar 31 | Warner Bros. | false |
| 15 | Basic Instinct 2 | - | - | - | $2,050,960 | 290 | $2,050,960 | Mar 31 | Entertainment Film Distributors | false |
| 16 | V for Vendetta | - | - | - | $1,638,065 | 410 | $20,863 | Oct 30 | Warner Bros. | false |
| 17 | Walk the Line | - | - | - | $1,628,243 | 290 | $17,780,351 | Feb 3 | 20th Century Fox International | false |
| 18 | The Ringer | - | - | - | $1,597,984 | 261 | $3,267,338 | Mar 24 | 20th Century Fox International | false |
| 19 | 16 Blocks | - | - | - | $1,421,498 | 302 | $4,251,554 | Apr 28 | Warner Bros. | false |
| 20 | Eight Below | - | - | - | $1,367,609 | 397 | $2,102,130 | Apr 21 | Buena Vista International | false |
| 21 | The Dark | - | - | - | $1,071,712 | 191 | $1,071,712 | Apr 7 | Momentum Pictures | false |
| 22 | Tristan + Isolde | - | - | - | $897,764 | 245 | $1,108,254 | Apr 21 | 20th Century Fox International | false |
| 23 | Slither | - | - | - | $891,487 | 321 | $2,179,983 | Apr 28 | Entertainment Film Distributors | false |
| 24 | Syriana | - | - | - | $865,590 | 236 | $7,162,144 | Mar 3 | Warner Bros. | false |
| 25 | Transamerica | - | - | - | $830,832 | 42 | $1,392,753 | Mar 24 | Pathé | false |
| 26 | Humko Deewana Kar Gaye | - | - | - | $768,084 | 38 | $899,334 | Apr 14 | UTV Motion Pictures | false |
| 27 | The Squid and the Whale | - | - | - | $760,641 | 24 | $1,229,887 | Apr 7 | Sony Pictures Releasing | false |
| 28 | The Three Burials of Melquiades Estrada | - | - | - | $621,792 | 29 | $720,843 | Mar 31 | Optimum Releasing | false |
| 29 | The White Countess | - | - | - | $486,279 | 57 | $540,512 | Mar 31 | Sony Pictures Releasing | false |
| 30 | Brokeback Mountain | - | - | - | $473,076 | 284 | $17,957,778 | Jan 6 | Entertainment Film Distributors | false |
| 31 | Tsotsi | - | - | - | $420,946 | 87 | $1,442,451 | Mar 17 | Momentum Pictures | false |
| 32 | The Hills Have Eyes | - | - | - | $405,723 | 331 | $6,255,176 | Mar 10 | 20th Century Fox International | false |
| 33 | The Mistress of Spices | - | - | - | $332,099 | 56 | $465,948 | Apr 21 | Entertainment Film Distributors | false |
| 34 | Memoirs of a Geisha | - | - | - | $323,801 | 288 | $12,663,017 | Jan 13 | Buena Vista International | false |
| 35 | Good Night, and Good Luck. | - | - | - | $316,849 | 139 | $4,400,071 | Feb 19 | Redbus Film Distribution | false |
| 36 | Pierrepoint: The Last Hangman | - | - | - | $301,320 | 18 | $429,706 | Apr 7 | Lionsgate | false |
| 37 | Junebug | - | - | - | $269,770 | 20 | $399,619 | Apr 14 | Miracle Films | false |
| 38 | Shooting Dogs 2006 Re-release | - | - | - | $240,705 | 20 | $286,065 | Mar 31 | Metrodome Distribution | false |
| 39 | Shaadi Se Pehle | - | - | - | $219,998 | 19 | $219,998 | Apr 7 | Tip Top Entertainment (TTE) | false |
| 40 | Deep Sea | - | - | - | $212,362 | 3 | $2,869,929 | Mar 3 | IMAX | false |
| 41 | Caché | - | - | - | $209,793 | 40 | $2,667,906 | Jan 27 | Artificial Eye | false |
| 42 | March of the Penguins | - | - | - | $186,023 | 163 | $5,490,891 | Dec 9 | Warner Bros. | false |
| 43 | Paradise Now | - | - | - | $156,883 | 14 | $257,795 | Apr 14 | Warner Bros. | false |
| 44 | The World's Fastest Indian | - | - | - | $119,299 | 78 | $840,237 | Mar 10 | Icon Film Distribution Australia | false |
| 45 | Romance & Cigarettes | - | - | - | $113,000 | 29 | $439,112 | Mar 24 | Icon Film Distribution Australia | false |
| 46 | C.R.A.Z.Y. | - | - | - | $112,834 | 28 | $175,862 | Apr 21 | Soda Pictures | false |
| 47 | Glastonbury | - | - | - | $101,826 | 18 | $170,118 | Apr 14 | Pathé | false |
| 48 | Rent | - | - | - | $95,078 | 61 | $95,078 | Apr 7 | Sony Pictures Releasing | false |
| 49 | Pyare Mohan | - | - | - | $91,643 | 15 | $91,643 | Apr 21 | Eros Worldwide | false |
| 50 | Chicken Little | - | - | - | $90,340 | 513 | $23,557,158 | Feb 10 | Buena Vista International | false |
| 51 | Rollin' with the Nines | - | - | - | $75,700 | 45 | $75,700 | Apr 21 | Maiden Voyage Pictures | false |
| 52 | The Proposition | - | - | - | $75,692 | 118 | $1,157,037 | Mar 10 | Tartan | false |
| 53 | Ballets Russes | - | - | - | $66,806 | 20 | $261,752 | Apr 21 | Revolver Entertainment | false |
| 54 | Freedomland | - | - | - | $62,274 | 78 | $130,490 | Apr 28 | Sony Pictures Releasing | false |
| 55 | Darna Zaroori Hai | - | - | - | $57,080 | 19 | $104,314 | Apr 28 | Tip Top Entertainment (TTE) | false |
| 56 | U-Carmen eKhayelitsha | - | - | - | $53,241 | 9 | $115,141 | Apr 21 | Tartan | false |
| 57 | Enron: The Smartest Guys in the Room | - | - | - | $37,182 | 25 | $303,736 | Apr 28 | Lionsgate | false |
| 58 | Côte d'Azur | - | - | - | $35,508 | 4 | $35,508 | Apr 14 | Peccadillo Pictures | false |
| 59 | Saawan - The Love Season | - | - | - | $35,171 | 17 | $35,171 | Apr 7 | Eros Worldwide | false |
| 60 | Don't Come Knocking | - | - | - | $19,181 | 10 | $40,404 | Apr 28 | Sony Pictures Releasing | false |
| 61 | Hell | - | - | - | $17,188 | 7 | $66,120 | Apr 21 | Momentum Pictures | false |
| 62 | Malamaal Weekly | - | - | - | $16,116 | 19 | $549,397 | Mar 10 | Tip Top Entertainment (TTE) | false |
| 63 | The Little Polar Bear 2: The Mysterious Island | - | - | - | $12,885 | 226 | $1,003,680 | Feb 10 | Warner Bros. | false |
| 64 | Greyfriars Bobby: The True Story of a Dog | - | - | - | $10,394 | 82 | $721,203 | Feb 10 | The Works UK Distribution | false |
| 65 | The Amateurs | - | - | - | $9,308 | 15 | $9,308 | Apr 28 | United International Pictures | false |
| 66 | Lucky Number Slevin | - | - | - | $6,964 | 326 | $7,956,571 | Feb 24 | Entertainment Film Distributors | false |
| 67 | Kidulthood | - | - | - | $6,663 | 42 | $849,650 | Mar 3 | Revolver Entertainment | false |
| 68 | New York Doll | - | - | - | $5,162 | 2 | $17,464 | Apr 7 | Optimum Releasing | false |
| 69 | Unknown White Male | - | - | - | $4,420 | 1 | $4,420 | Apr 7 | - | false |
| 70 | The Ballad of Jack and Rose | - | - | - | $4,366 | 3 | $37,698 | Mar 31 | Entertainment Film Distributors | false |
| 71 | The Child | - | - | - | $4,307 | 3 | $234,477 | Mar 10 | Artificial Eye | false |
| 72 | The Weather Man | - | - | - | $3,495 | 258 | $1,947,395 | Mar 3 | Momentum Pictures | false |
| 73 | Ice Age 2: The Meltdown | - | - | - | $0 | 503 | $52,332,021 | Apr 7 | 20th Century Fox International | true |
