| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $250,863,268 | 3,768 | $30,433,781 | 12.1% | 3,685 | Dec 22 | Jun 24 | Twentieth Century Fox | false |
| 2 | The Pursuit of Happyness | - | - | - | $163,566,459 | 3,169 | $26,541,709 | 16.2% | 2,852 | Dec 15 | Mar 18 | Sony Pictures Releasing | false |
| 3 | Dreamgirls | - | - | - | $103,365,956 | 2,797 | $378,950 | 0.4% | 3 | Dec 15 | Apr 19 | DreamWorks | false |
| 4 | Charlotte's Web | - | - | - | $82,985,708 | 3,745 | $11,457,353 | 13.8% | 3,566 | Dec 15 | Mar 22 | Paramount Pictures | false |
| 5 | Eragon | - | - | - | $75,030,163 | 3,030 | $23,239,907 | 31% | 3,020 | Dec 15 | Apr 8 | Twentieth Century Fox | false |
| 6 | Rocky Balboa | - | - | - | $70,270,943 | 3,019 | $12,158,168 | 17.3% | 3,017 | Dec 20 | Mar 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 7 | The Holiday | - | - | - | $63,224,849 | 2,698 | $12,778,913 | 20.2% | 2,610 | Dec 8 | Jan 28 | Sony Pictures Releasing | false |
| 8 | The Good Shepherd | - | - | - | $59,952,835 | 2,250 | $9,912,110 | 16.5% | 2,215 | Dec 22 | Mar 8 | Universal Pictures | false |
| 9 | Blood Diamond | - | - | - | $57,377,916 | 1,920 | $8,648,324 | 15.1% | 1,910 | Dec 8 | Apr 12 | Warner Bros. | false |
| 10 | Apocalypto | - | - | - | $50,866,635 | 2,465 | $15,005,604 | 29.5% | 2,465 | Dec 8 | Mar 8 | Walt Disney Studios Motion Pictures | false |
| 11 | We Are Marshall | - | - | - | $43,545,364 | 2,606 | $6,114,264 | 14% | 2,606 | Dec 22 | Mar 8 | Warner Bros. | false |
| 12 | Pan's Labyrinth | - | - | - | $37,634,615 | 1,143 | $568,641 | 1.5% | 17 | Dec 29 | Jun 14 | Picturehouse | false |
| 13 | The Nativity Story | - | - | - | $37,629,831 | 3,083 | $8,025,000 | - | 3,083 | Dec 1 | Jan 18 | New Line Cinema | true |
| 14 | Children of Men | - | - | - | $35,552,383 | 1,524 | $501,003 | 1.4% | 16 | Dec 25 | Mar 15 | Universal Pictures | false |
| 15 | Notes on a Scandal | - | - | - | $17,510,118 | 682 | $414,487 | 2.4% | 22 | Dec 25 | May 24 | Fox Searchlight Pictures | false |
| 16 | Unaccompanied Minors | - | - | - | $16,655,224 | 2,775 | $5,815,474 | 34.9% | 2,775 | Dec 8 | Mar 8 | Warner Bros. | false |
| 17 | Black Christmas | - | - | - | $16,273,581 | 1,544 | $3,723,364 | 22.9% | 1,544 | Dec 25 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 18 | Arthur and the Invisibles | - | - | - | $15,132,763 | 2,248 | - | - | - | Dec 29 | May 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 19 | Letters from Iwo Jima | - | - | - | $13,756,082 | 781 | $89,097 | 0.6% | 5 | Dec 20 | Apr 26 | Warner Bros. | false |
| 20 | The Painted Veil | - | - | - | $8,060,487 | 287 | $51,086 | 0.6% | 4 | Dec 20 | Apr 26 | Warner Independent Pictures (WIP) | false |
| 21 | Turistas | - | - | - | $7,027,762 | 1,572 | $3,582,554 | 51% | 1,570 | Dec 1 | Jan 25 | Fox Atomic | false |
| 22 | Curse of the Golden Flower | - | - | - | $6,566,773 | 1,234 | $184,000 | 2.8% | 60 | Dec 21 | Mar 29 | Sony Pictures Classics | false |
| 23 | Van Wilder: The Rise of Taj | - | - | - | $4,300,645 | 1,979 | $2,313,372 | 53.8% | 1,979 | Dec 1 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 24 | Venus | - | - | - | $3,347,411 | 168 | $35,604 | 1.1% | 3 | Dec 21 | Apr 12 | Miramax | false |
| 25 | Miss Potter | - | - | - | $3,005,605 | 102 | $9,653 | 0.3% | 2 | Dec 29 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 26 | Perfume: The Story of a Murderer | - | - | - | $2,223,293 | 280 | $37,079 | 1.7% | 3 | Dec 27 | Mar 1 | DreamWorks | false |
| 27 | Factory Girl | - | - | - | $1,675,241 | 336 | - | - | - | Dec 29 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 28 | Romeo and Juliet | - | - | - | $1,386,582 | 73 | $356,907 | 25.7% | 73 | Dec 15 | - | Alliance Atlantis Vivafilm | false |
| 29 | The Good German | - | - | - | $1,308,696 | 66 | $76,817 | 5.9% | 5 | Dec 15 | Apr 12 | Warner Bros. | false |
| 30 | Breaking and Entering | - | - | - | $930,469 | 95 | - | - | - | Dec 15 | Apr 26 | The Weinstein Company | false |
| 31 | Inland Empire | - | - | - | $861,355 | 15 | $27,508 | - | 2 | Dec 6 | May 20 | 518 Media | true |
| 32 | Guadalupe: El Milagro Y El Mensaje | - | - | - | $848,139 | 225 | $301,333 | - | 225 | Dec 8 | Jan 1 | Slowhand Cinema Releasing | true |
| 33 | Bhagam Bhag | - | - | - | $789,963 | 51 | $252,988 | 32% | 51 | Dec 22 | Jan 7 | Rainbow Releasing | false |
| 34 | Days of Glory | - | - | - | $320,700 | 29 | $10,996 | 3.4% | 2 | Dec 6 | Apr 26 | The Weinstein Company | false |
| 35 | Kabul Express | - | - | - | $302,458 | 50 | $142,591 | 47.1% | 50 | Dec 15 | Jan 11 | Yash Raj Films | false |
| 36 | 10 Items or Less | - | - | - | $83,291 | 15 | $35,929 | 43.1% | 15 | Dec 1 | Dec 21 | THINKFilm | false |
| 37 | El Topo | - | - | - | $80,302 | 4 | $6,857 | 8.5% | 1 | Dec 13 | Jul 12 | ABKCO Films | false |
| 38 | Unconscious | - | - | - | $68,501 | 5 | $807 | 1.2% | 1 | Dec 29 | Aug 23 | Regent Releasing | false |
| 39 | Screamers | - | - | - | $52,034 | 4 | $23,609 | 45.4% | 4 | Dec 8 | Dec 25 | Maya Entertainment | false |
| 40 | Home of the Brave | - | - | - | $51,708 | 44 | $6,000 | 11.6% | 3 | Dec 15 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 41 | Two Weeks | - | - | - | $47,986 | 12 | - | - | - | Dec 1 | - | Metro-Goldwyn-Mayer (MGM) | false |
| 42 | Family Law | - | - | - | $38,605 | 6 | $5,384 | 13.9% | 2 | Dec 6 | Mar 15 | IFC Films | false |
| 43 | Monkey Warfare | - | - | - | $36,875 | 3 | $1,366 | 3.7% | 1 | Dec 8 | May 20 | Alliance Atlantis Vivafilm | false |
| 44 | Off the Black | - | - | - | $24,425 | 4 | $6,763 | 27.7% | 2 | Dec 8 | Feb 15 | THINKFilm | false |
| 45 | The Secret Life of Words | - | - | - | $20,678 | 3 | $5,309 | 25.7% | 1 | Dec 15 | May 10 | Strand Releasing | false |
| 46 | Words of My Perfect Teacher | - | - | - | $20,318 | 3 | $2,300 | 11.3% | 3 | Dec 22 | Feb 15 | International Film Circuit | false |
| 47 | The Dead Girl | - | - | - | $19,875 | 2 | $6,613 | 33.3% | 2 | Dec 29 | Jan 11 | First Look International | false |
| 48 | Ever Again | - | - | - | $17,304 | 12 | $10,802 | 62.4% | 12 | Dec 8 | Dec 14 | Rocky Mountain Pictures | false |
| 49 | Matthew Barney: No Restraint | - | - | - | $16,136 | 6 | $1,241 | 7.7% | 1 | Dec 20 | Mar 4 | IFC Films | false |
| 50 | The Architect | - | - | - | $13,737 | 8 | $2,032 | 14.8% | 1 | Dec 1 | Dec 21 | Magnolia Pictures | false |
| 51 | Christmas at Maxwell's | - | - | - | $12,781 | 41 | $8,375 | 65.5% | 41 | Dec 1 | Dec 14 | Aloha Releasing Inc. | false |
| 52 | The Tiger and the Snow | - | - | - | $10,167 | 4 | $3,701 | 36.4% | 4 | Dec 29 | Jan 11 | Strand Releasing | false |
| 53 | Dreamland | - | - | - | $6,383 | 5 | $4,350 | 68.1% | 5 | Dec 1 | Dec 7 | Truly Indie | false |
| 54 | Unnatural & Accidental | - | - | - | $5,420 | 2 | $3,348 | 61.8% | 2 | Dec 1 | Dec 10 | Alliance Atlantis Vivafilm | false |
| 55 | Four Eyed Monsters | - | - | - | $3,135 | 1 | $1,886 | 60.2% | 1 | Dec 1 | Dec 7 | Four Eyed Monsters | false |
| 56 | The Empire in Africa | - | - | - | $1,088 | 3 | $1,088 | 100% | 3 | Dec 8 | Dec 10 | Cinema Libre Studio | false |
