| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | X-Men Origins: Wolverine | - | - | - | $13,234,821 | 416 | $14,924,362 | Apr 29 | 20th Century Fox International | false |
| 2 | Star Trek | - | - | - | $10,784,776 | 317 | $12,650,526 | May 7 | Paramount Pictures International | false |
| 3 | Angels & Demons | - | - | - | $10,782,487 | 434 | $14,065,391 | May 14 | Sony Pictures Releasing | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $7,187,171 | 397 | $14,037,398 | May 21 | 20th Century Fox International | false |
| 5 | Ghosts of Girlfriends Past | - | - | - | $4,554,000 | 219 | $5,227,478 | May 7 | Roadshow Films | false |
| 6 | Fast & Furious | - | - | - | $3,211,767 | 345 | $13,665,948 | Apr 9 | Universal Pictures International (UPI) | false |
| 7 | Defiance | - | - | - | $2,758,168 | 174 | $2,934,207 | Apr 30 | Roadshow Films | false |
| 8 | Monsters vs. Aliens | - | - | - | $2,264,788 | 382 | $16,257,222 | Apr 2 | Paramount Pictures International | false |
| 9 | 17 Again | - | - | - | $1,903,033 | 223 | $10,079,700 | Apr 9 | Roadshow Films | false |
| 10 | The Boy in the Striped Pajamas | - | - | - | $1,723,912 | 120 | $2,929,712 | Apr 23 | Walt Disney Pictures | false |
| 11 | State of Play | - | - | - | $1,585,671 | 245 | $5,702,156 | May 28 | Universal Pictures International (UPI) | false |
| 12 | Samson & Delilah | - | - | - | $981,175 | 38 | $2,427,981 | May 7 | Paramount Pictures International | false |
| 13 | Observe and Report | - | - | - | $912,486 | 130 | $912,486 | May 14 | Warner Bros. | false |
| 14 | The Boat That Rocked | - | - | - | $690,199 | 293 | $4,251,228 | Apr 9 | Universal Pictures International (UPI) | false |
| 15 | Race to Witch Mountain | - | - | - | $538,615 | 289 | $5,322,485 | Apr 9 | Walt Disney Pictures | false |
| 16 | The Reader | - | - | - | $446,738 | 53 | $3,436,114 | Feb 19 | Roadshow Films | false |
| 17 | Knowing | - | - | - | $445,569 | 204 | $5,795,063 | Mar 26 | Icon Film Distribution Australia | false |
| 18 | Fired Up! | - | - | - | $362,714 | 128 | $941,069 | Apr 23 | Sony Pictures Releasing | false |
| 19 | Mary and Max | - | - | - | $348,845 | 67 | $1,005,363 | Apr 9 | Icon Film Distribution Australia | false |
| 20 | I Love You, Man | - | - | - | $281,561 | 187 | $3,487,256 | Jun 4 | Paramount Pictures International | false |
| 21 | Gomorrah | - | - | - | $257,904 | 19 | $363,962 | May 14 | Madman Entertainment | false |
| 22 | What Just Happened | - | - | - | $253,203 | 37 | $304,421 | May 21 | Hopscotch Films | false |
| 23 | Elegy | - | - | - | $211,672 | 40 | $740,624 | Apr 9 | Hopscotch Films | false |
| 24 | Easy Virtue | - | - | - | $195,269 | 75 | $1,996,738 | Mar 12 | Hopscotch Films | false |
| 25 | My Year Without Sex | - | - | - | $176,033 | 25 | $795,162 | May 21 | Paramount Pictures International | false |
| 26 | Tulpan | - | - | - | $175,781 | 25 | $329,753 | Apr 23 | Palace Films | false |
| 27 | Children of Winter | - | - | - | $173,620 | 3 | $220,214 | May 21 | - | false |
| 28 | The Baader Meinhof Complex | - | - | - | $170,077 | 20 | $170,077 | May 7 | Icon Film Distribution Australia | false |
| 29 | Paris 36 | - | - | - | $145,063 | 12 | $145,063 | Apr 30 | Sony Pictures Releasing | false |
| 30 | Jonas Brothers: The 3D Concert Experience | - | - | - | $105,369 | 47 | $105,369 | May 14 | Walt Disney Pictures | false |
| 31 | Vampire Killers | - | - | - | $100,104 | 40 | $100,104 | May 21 | Paramount Pictures International | false |
| 32 | Iron Maiden: Flight 666 | - | - | - | $74,134 | 26 | $74,134 | Apr 30 | - | false |
| 33 | Synecdoche, New York | - | - | - | $67,856 | 5 | $67,856 | May 7 | Roadshow Films | false |
| 34 | Adventureland | - | - | - | $48,742 | 41 | $95,215 | May 28 | Roadshow Films | false |
| 35 | Duplicity | - | - | - | $39,830 | 224 | $3,799,322 | Mar 19 | Universal Pictures International (UPI) | false |
| 36 | Tenderness | - | - | - | $36,524 | 35 | $66,367 | Apr 30 | Hoyts Distribution | false |
| 37 | Summer Hours | - | - | - | $35,033 | 25 | $641,751 | Apr 2 | Palace Films | false |
| 38 | Quiet Chaos | - | - | - | $26,973 | 12 | $26,973 | May 14 | Sharmill Films | false |
| 39 | The Merchants of Bollywood | - | - | - | $20,691 | 21 | $20,691 | May 28 | - | false |
| 40 | Is Anybody There? | - | - | - | $19,218 | 42 | $456,345 | Jun 4 | Hopscotch Films | false |
| 41 | Katyn | - | - | - | $16,841 | 10 | $16,841 | May 28 | - | false |
| 42 | Paul Blart: Mall Cop | - | - | - | $13,310 | 196 | $3,733,141 | Mar 19 | Sony Pictures Releasing | false |
| 43 | The Voyage That Shook the World | - | - | - | $8,708 | 7 | $8,708 | May 21 | Con Dios Entertainment | false |
| 44 | The Chifleys of Busby Street | - | - | - | $2,941 | 3 | $2,941 | May 21 | Ronin Films | false |
| 45 | The Alps | - | - | - | $484 | 1 | $13,467 | Jun 4 | IMAX | false |
| 46 | RiP: A Remix Manifesto | - | - | - | $419 | 1 | $419 | May 21 | Gil Scrine Films | false |
