Domestic Box Office For May 2021
Key:Estimated
| Rank | Release | Gross | Max Th | Opening | % of Total | Open Th | Open | Close | Distributor |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A Quiet Place Part II | $160,072,261 | 3,744 | $47,547,231 | 29.7% | 3,726 | May 28 | - | Paramount Pictures |
| 2 | Cruella | $86,103,234 | 3,922 | $21,496,997 | 25% | 3,892 | May 28 | - | Walt Disney Studios Motion Pictures |
| 3 | Wrath of Man | $27,466,489 | 3,007 | $8,309,007 | 30.3% | 2,875 | May 7 | - | United Artists Releasing |
| 4 | Spiral | $23,216,862 | 2,991 | $8,750,034 | 37.7% | 2,811 | May 14 | - | Lionsgate |
| 5 | Those Who Wish Me Dead | $7,407,200 | 3,379 | $2,831,382 | 38.2% | 3,188 | May 14 | - | Warner Bros. |
| 6 | Dream Horse | $2,913,328 | 1,284 | $794,741 | 27.3% | 1,254 | May 21 | - | Bleecker Street Media |
| 7 | Here Today | $2,807,494 | 1,230 | $1,042,171 | 37.1% | 1,200 | May 7 | - | Stage 6 Films |
| 8 | Finding You | $2,753,985 | 1,447 | $920,476 | 33.4% | 1,312 | May 14 | - | Roadside Attractions |
| 9 | Scoob! | $2,188,425 | - | $850,000 | - | 2,500 | May 21 | - | Warner Bros. |
| 10 | Profile | $1,744,740 | 2,104 | $730,290 | 41.9% | 2,033 | May 14 | - | Focus Features |
| 11 | Top Gun 2021 Re-release | $457,577 | 153 | $214,654 | 46.9% | 153 | May 14 | - | Paramount Pictures |
| 12 | World War Z 2021 Re-release | $448,000 | 80 | $347,000 | - | 80 | May 28 | - | Paramount Pictures |
| 13 | The Water Man | $383,234 | 311 | $181,046 | 47.2% | 311 | May 7 | - | RLJ Entertainment |
| 14 | The Dry | $364,237 | 186 | $119,364 | 32.8% | 186 | May 21 | - | IFC Films |
| 15 | Dad, I'm Sorry | $350,000 | - | $350,000 | - | 20 | May 28 | - | 3388 Films |
| 16 | Final Account | $308,976 | 308 | $139,985 | 45.3% | 308 | May 21 | - | Focus Features |
| 17 | New Order | $303,556 | 236 | $144,533 | 47.6% | 236 | May 21 | - | Neon |
| 18 | The Swimming Pool 2021 Re-release | $211,467 | 10 | $3,867 | 1.8% | 1 | May 14 | - | Rialto Distribution |
| 19 | The Djinn | $124,772 | 44 | $50,312 | 40.3% | 41 | May 14 | - | IFC Films |
| 20 | Walking with Herb | $120,226 | 507 | $69,337 | 57.7% | 507 | May 7 | - | Fathom Events |
| 21 | The Paper Tigers | $112,691 | 65 | $46,615 | 41.4% | 65 | May 7 | - | Well Go USA Entertainment |
| 22 | Mission Stories | $87,059 | 44 | $24,388 | 28% | 44 | May 7 | - | Excel Entertainment |
| 23 | My Love | $86,252 | 25 | $29,432 | 34.1% | 25 | May 7 | - | CMC Pictures |
| 24 | Riders of Justice | $77,115 | 18 | $15,441 | 20% | 17 | May 14 | - | Magnolia Pictures |
| 25 | The Killing of Two Lovers | $71,162 | 36 | $25,378 | 35.7% | 34 | May 14 | - | Neon |
| 26 | The Human Factor | $36,693 | 90 | $15,549 | 42.4% | 90 | May 7 | - | Sony Pictures Classics |
| 27 | Mainstream | $35,696 | 76 | $19,745 | 55.3% | 76 | May 7 | - | IFC Films |
| 28 | The Perfect Candidate | $30,134 | 17 | $2,795 | 9.3% | 5 | May 14 | - | Music Box Films |
| 29 | Equal Standard | $15,938 | 25 | $15,938 | 100% | 25 | May 7 | - | Mutiny Pictures |
| 30 | American Traitor: The Trial of Axis Sally | $14,000 | - | $14,000 | - | - | May 28 | - | Vertical Entertainment |
| 31 | State Funeral | $11,342 | 2 | $3,810 | 33.6% | 2 | May 7 | - | MUBI |
| 32 | There Is No Evil | $8,063 | 7 | $3,242 | 40.2% | 7 | May 14 | - | Kino Lorber |
| 33 | Ghost Master | $6,136 | 2 | $4,212 | 68.6% | 2 | May 14 | - | Indican Pictures |
| 34 | Paper Spiders | $2,992 | 17 | $2,992 | 100% | 17 | May 7 | - | Entertainment Squad |
| 35 | The Unthinkable | $974 | 3 | $655 | 67.2% | 3 | May 7 | - | Magnolia Pictures |
| 36 | Funhouse | $507 | 3 | $251 | 49.5% | 3 | May 28 | - | Magnet Releasing |
