| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Wallace & Gromit: The Curse of the Were-Rabbit | $18,741,841 | - | 3,645 | - | $5,141 | $18,763,028 | 1 | DreamWorks Distribution | true | false |
| 2 | - | Flightplan | $12,087,368 | - | 3,323 | - | $3,637 | $62,239,577 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 3 | - | In Her Shoes | $11,298,090 | - | 2,808 | - | $4,023 | $11,298,090 | 1 | Twentieth Century Fox | true | false |
| 4 | - | Two for the Money | $9,815,055 | - | 2,391 | - | $4,105 | $9,815,055 | 1 | Universal Pictures | true | false |
| 5 | - | The Gospel | $8,191,979 | - | 969 | - | $8,454 | $8,191,979 | 1 | Screen Gems | true | false |
| 6 | - | Corpse Bride | $7,433,675 | - | 3,004 | - | $2,474 | $43,038,367 | 4 | Warner Bros. | false | false |
| 7 | - | Waiting... | $6,872,387 | - | 1,652 | - | $4,160 | $6,872,387 | 1 | Lionsgate | true | false |
| 8 | - | Serenity | $6,052,570 | - | 2,189 | - | $2,764 | $18,721,355 | 2 | Universal Pictures | false | false |
| 9 | - | A History of Violence | $5,826,000 | - | 1,340 | - | $4,347 | $17,398,000 | 3 | New Line Cinema | false | true |
| 10 | - | Into the Blue | $5,406,272 | - | 2,789 | - | $1,938 | $14,479,017 | 2 | Sony Pictures Releasing | false | false |
| 11 | - | The Greatest Game Ever Played | $4,542,730 | - | 1,810 | - | $2,509 | $9,317,992 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 12 | - | Just Like Heaven | $3,882,021 | - | 2,307 | - | $1,682 | $44,050,189 | 4 | DreamWorks Distribution | false | false |
| 13 | - | The Exorcism of Emily Rose | $2,696,326 | - | 1,827 | - | $1,475 | $72,385,109 | 5 | Screen Gems | false | false |
| 14 | - | The 40-Year-Old Virgin | $2,088,545 | - | 1,135 | - | $1,840 | $104,571,208 | 8 | Universal Pictures | false | false |
| 15 | - | Roll Bounce | $1,952,839 | - | 888 | - | $2,199 | $15,350,320 | 3 | - | false | false |
| 16 | - | Proof | $1,482,447 | - | 517 | - | $2,867 | $4,388,447 | 4 | Miramax | false | true |
| 17 | - | Lord of War | $791,743 | - | 550 | - | $1,439 | $23,387,720 | 4 | Lionsgate | false | false |
| 18 | - | March of the Penguins | $558,199 | - | 469 | - | $1,190 | $75,477,637 | 16 | Warner Independent Pictures (WIP) | false | false |
| 19 | - | Oliver Twist | $501,012 | - | 779 | - | $643 | $1,804,620 | 3 | Sony Pictures Releasing | false | false |
| 20 | - | Good Night, and Good Luck. | $488,950 | - | 11 | - | $44,450 | $488,950 | 1 | Warner Independent Pictures (WIP) | true | false |
| 21 | - | Charlie and the Chocolate Factory | $416,320 | - | 454 | - | $917 | $204,975,605 | 13 | Warner Bros. | false | false |
| 22 | - | Transporter 2 | $347,726 | - | 318 | - | $1,093 | $42,419,304 | 6 | Twentieth Century Fox | false | false |
| 23 | - | War of the Worlds | $250,671 | - | 245 | - | $1,023 | $233,604,519 | 15 | Paramount Pictures | false | false |
| 24 | - | Everything Is Illuminated | $250,489 | - | 85 | - | $2,946 | $776,946 | 4 | Warner Independent Pictures (WIP) | false | false |
| 25 | - | Four Brothers | $168,744 | - | 154 | - | $1,095 | $73,639,757 | 9 | Paramount Pictures | false | false |
| 26 | - | Madagascar | $166,539 | - | 252 | - | $660 | $193,166,575 | 20 | DreamWorks Distribution | false | false |
| 27 | - | Separate Lies | $158,006 | - | 59 | - | $2,678 | $313,984 | 4 | - | false | false |
| 28 | - | Fantastic Four | $145,135 | - | 203 | - | $714 | $154,247,781 | 14 | Twentieth Century Fox | false | false |
| 29 | - | Red Eye | $125,728 | - | 214 | - | $587 | $57,867,903 | 8 | DreamWorks Distribution | false | false |
| 30 | - | The Prize Winner of Defiance, Ohio | $120,058 | - | 41 | - | $2,928 | $341,588 | 2 | DreamWorks Distribution | false | false |
| 31 | - | The Constant Gardener | $118,880 | - | 469 | - | $253 | $31,371,149 | 6 | Focus Features | false | false |
| 32 | - | The Dukes of Hazzard | $116,752 | - | 311 | - | $375 | $80,120,841 | 10 | Warner Bros. | false | false |
| 33 | - | Mr. & Mrs. Smith | $114,505 | - | 140 | - | $817 | $185,938,653 | 18 | Twentieth Century Fox | false | false |
| 34 | - | The Skeleton Key | $103,485 | - | 158 | - | $654 | $47,622,860 | 9 | Universal Pictures | false | false |
| 35 | - | An Unfinished Life | $93,000 | - | 428 | - | $217 | $8,264,735 | 5 | Miramax | false | false |
| 36 | - | Grizzly Man | $91,879 | - | 62 | - | $1,481 | $2,797,972 | 9 | Lionsgate | false | false |
| 37 | - | Batman Begins | $78,541 | - | 161 | - | $487 | $205,205,347 | 17 | Warner Bros. | false | false |
| 38 | - | Capote | $55,372 | - | 24 | - | $2,307 | $942,903 | 2 | Sony Pictures Classics | false | false |
| 39 | - | Duma | $51,871 | - | 36 | - | $1,440 | $816,461 | 25 | Warner Bros. | false | false |
| 40 | - | Little Manhattan | $37,550 | - | 2 | - | $18,775 | $88,141 | 2 | Twentieth Century Fox | false | false |
| 41 | - | Star Wars: Episode III - Revenge of the Sith | $25,956 | - | 38 | - | $683 | $380,243,785 | 21 | Twentieth Century Fox | false | false |
| 42 | - | Must Love Dogs | $15,427 | - | 38 | - | $405 | $43,694,795 | 11 | Warner Bros. | false | false |
| 43 | - | Mad Hot Ballroom | $10,311 | - | 20 | - | $515 | $8,007,332 | 22 | Paramount Classics | false | false |
| 44 | - | Hustle & Flow | $3,736 | - | 9 | - | $415 | $22,191,069 | 12 | Paramount Classics | false | false |
| 45 | - | Après Vous | $872 | - | 3 | - | $290 | $825,334 | 19 | Paramount Classics | false | false |
| 46 | - | Cinderella Man | $740 | - | 4 | - | $185 | $61,609,460 | 19 | Universal Pictures | false | false |
| 47 | - | Asylum | $504 | - | 3 | - | $168 | $372,393 | 9 | Paramount Classics | false | false |
