| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Mission: Impossible III | $5,209,642 | -47.4% | 511 | -1 | $10,194 | $18,404,031 | 2 | United International Pictures | false | false |
| 2 | - | Prime | $1,611,742 | - | 383 | - | $4,208 | $1,611,742 | 1 | Momentum Pictures | true | false |
| 3 | - | When a Stranger Calls | $935,500 | - | 304 | - | $3,077 | $935,500 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Ice Age: The Meltdown | $844,737 | -21.6% | 448 | -19 | $1,885 | $53,717,420 | 6 | 20th Century Fox International | false | false |
| 5 | 2 | Confetti | $814,388 | -30.4% | 300 | - | $2,714 | $2,611,812 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | Silent Hill | $440,142 | -30.8% | 285 | -15 | $1,544 | $6,331,297 | 4 | Pathé | false | false |
| 7 | 5 | 16 Blocks | $400,784 | -29.9% | 263 | -39 | $1,523 | $3,803,482 | 3 | Warner Bros. | false | false |
| 8 | - | Brick | $270,500 | - | 43 | - | $6,290 | $270,500 | 1 | Optimum Releasing | true | false |
| 9 | 9 | She's the Man | $191,134 | -21.5% | 197 | -29 | $970 | $8,470,360 | 6 | Entertainment Film Distributors | false | false |
| 10 | 6 | Scary Movie 4 | $174,265 | -51.7% | 177 | -137 | $984 | $10,972,741 | 5 | Buena Vista International | false | false |
| 11 | 7 | American Dreamz | $138,514 | -58.9% | 179 | -99 | $773 | $4,086,253 | 4 | United International Pictures | false | false |
| 12 | 10 | Inside Man | $129,040 | -33.6% | 81 | -38 | $1,593 | $15,225,572 | 8 | United International Pictures | false | false |
| 13 | 11 | 36 China Town | $115,165 | -24.7% | 34 | - | $3,387 | $358,911 | 2 | - | false | false |
| 14 | 8 | Slither | $114,008 | -61.9% | 163 | -125 | $699 | $2,116,000 | 3 | Entertainment Film Distributors | false | false |
| 15 | 12 | Eight Below | $84,777 | -31.6% | 182 | -96 | $465 | $2,034,672 | 4 | Buena Vista International | false | false |
| 16 | 16 | The Shaggy Dog | $68,855 | -0.8% | 129 | -33 | $533 | $5,403,338 | 7 | Buena Vista International | false | false |
| 17 | 15 | The Squid and the Whale | $51,965 | -25.9% | 24 | - | $2,165 | $1,058,317 | 6 | Sony Pictures Releasing | false | false |
| 18 | 13 | Take the Lead | $49,578 | -54.1% | 67 | -60 | $739 | $4,242,062 | 6 | Entertainment Film Distributors | false | false |
| 19 | - | Time to Leave | $46,645 | - | 16 | - | $2,915 | $46,645 | 1 | Artificial Eye | true | false |
| 20 | 18 | Yours, Mine & Ours | $37,389 | +19.7% | 78 | -8 | $479 | $2,502,060 | 7 | Sony Pictures Releasing | false | false |
| 21 | 14 | An American Haunting | $36,234 | -51% | 54 | -36 | $671 | $3,397,077 | 5 | Lionsgate | false | false |
| 22 | 20 | Enron: The Smartest Guys in the Room | $22,668 | -22.8% | 9 | +3 | $2,518 | $140,793 | 3 | Lionsgate | false | false |
| 23 | - | Tathastu | $21,374 | - | 17 | - | $1,257 | $21,374 | 1 | - | true | false |
| 24 | 38 | The Three Burials of Melquiades Estrada | $20,937 | +78.6% | 11 | -2 | $1,903 | $710,931 | 7 | Optimum Releasing | false | false |
| 25 | 21 | Walk the Line | $20,515 | -25.6% | 26 | -4 | $789 | $19,155,303 | 15 | 20th Century Fox International | false | false |
| 26 | - | Tom, Dick, and Harry | $17,287 | - | 8 | - | $2,160 | $17,287 | 1 | Venus | true | false |
| 27 | 28 | Transamerica | $16,333 | -8.6% | 17 | +2 | $960 | $1,365,638 | 8 | Pathé | false | false |
| 28 | 33 | The Pink Panther | $16,157 | +10.6% | 46 | -9 | $351 | $11,421,458 | 9 | 20th Century Fox International | false | false |
| 29 | 26 | Junebug | $16,026 | -18.9% | 11 | +4 | $1,456 | $365,837 | 5 | Miracle Films | false | false |
| 30 | 23 | Humko Deewana Kar Gaye | $15,914 | -35.9% | 20 | -4 | $795 | $899,334 | 5 | UTV Motion Pictures | false | false |
| 31 | 24 | The Devil and Daniel Johnston | $12,876 | -42.8% | 10 | - | $1,287 | $62,109 | 2 | Tartan | false | false |
| 32 | 19 | Tristan + Isolde | $12,368 | -60.4% | 16 | -28 | $773 | $1,151,995 | 4 | 20th Century Fox International | false | false |
| 33 | - | V for Vendetta | $11,738 | - | 5 | - | $2,347 | $6,757,039 | - | Warner Bros. | - | false |
| 34 | - | Quo Vadis, Baby? | $11,454 | - | 6 | - | $1,909 | $11,454 | 1 | - | true | false |
| 35 | 22 | The Mistress of Spices | $11,316 | -55% | 14 | -11 | $808 | $456,280 | 4 | Entertainment Film Distributors | false | false |
| 36 | 31 | Capote | $9,640 | -39.5% | 16 | -8 | $602 | $2,859,282 | 12 | Sony Pictures Releasing | false | false |
| 37 | 25 | Syriana | $9,413 | -55.5% | 13 | -7 | $724 | $7,204,324 | 11 | Warner Bros. | false | false |
| 38 | 35 | Fateless | $9,392 | -27.2% | 3 | -1 | $3,130 | $29,627 | 2 | Periscoop Film | false | false |
| 39 | 30 | Ballets Russes | $9,282 | -42.1% | 6 | -1 | $1,547 | $130,551 | 4 | Revolver Entertainment | false | false |
| 40 | 17 | Love + Hate | $8,499 | -80.1% | 18 | -26 | $472 | $79,934 | 2 | Verve Pictures | false | false |
| 41 | 42 | Paradise Now | $8,499 | -0.9% | 7 | +1 | $1,214 | $207,179 | 5 | Warner Bros. | false | false |
| 42 | 49 | Romance & Cigarettes | $8,434 | +19.7% | 12 | +7 | $702 | $413,697 | 8 | Icon Film Distribution | false | false |
| 43 | - | Initial D | $8,090 | - | 15 | - | $539 | $8,090 | 1 | Contender Entertainment Group | true | false |
| 44 | 29 | The Little Polar Bear 2: The Mysterious Island | $7,353 | -55.4% | 35 | -32 | $210 | $1,003,680 | 14 | Warner Bros. | false | false |
| 45 | 39 | Tsotsi | $7,247 | -33.4% | 13 | +1 | $557 | $1,435,636 | 9 | Momentum Pictures | false | false |
| 46 | - | Kidulthood | $7,062 | - | 7 | - | $1,008 | $849,650 | 11 | Revolver Entertainment | false | false |
| 47 | - | Wal-Mart: The High Cost of Low Price | $6,772 | - | 4 | - | $1,693 | $6,772 | 1 | Tartan | true | false |
| 48 | 43 | Failure to Launch | $6,607 | -22.3% | 7 | +1 | $943 | $5,578,118 | 7 | United International Pictures | false | false |
| 49 | 40 | U-Carmen eKhayelitsha | $6,132 | -42% | 7 | -1 | $876 | $95,799 | 4 | Tartan | false | false |
