| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ratatouille | $4,564,850 | -27.4% | 624 | -34 | $7,315 | $14,072,500 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Live Free or Die Hard | $1,787,441 | - | 360 | - | $4,965 | $1,787,441 | 1 | 20th Century Fox International | true | false |
| 3 | - | Elizabeth: The Golden Age | $1,748,045 | - | 323 | - | $5,411 | $1,748,045 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | 2061: Un anno eccezionale | $1,072,252 | - | 378 | - | $2,836 | $1,072,252 | 1 | 01 Distribution | true | false |
| 5 | - | Days and Clouds | $1,044,373 | - | 176 | - | $5,933 | $1,044,524 | 1 | Warner Bros. | true | false |
| 6 | 2 | SMS - Sotto mentite spoglie | $851,311 | -42.8% | 160 | -139 | $5,320 | $5,593,883 | 3 | Medusa Distribuzione | false | false |
| 7 | 3 | Knocked Up | $563,300 | -39.9% | 176 | -79 | $3,200 | $1,893,560 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | - | Silk | $512,339 | - | 197 | - | $2,600 | $512,367 | 1 | Medusa Distribuzione | true | false |
| 9 | 5 | Stardust | $274,279 | -60.9% | 112 | -135 | $2,448 | $2,897,216 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 4 | Michael Clayton | $254,644 | -64.6% | 79 | -149 | $3,223 | $5,640,817 | 4 | Medusa Distribuzione | false | false |
| 11 | - | Youth Without Youth | $243,865 | - | 77 | - | $3,167 | $243,865 | 1 | BIM Distribuzione | true | false |
| 12 | 9 | The Right Distance | $205,647 | -16.5% | 74 | -28 | $2,779 | $602,119 | 2 | 01 Distribution | false | false |
| 13 | 6 | Resident Evil: Extinction | $165,426 | -71.6% | 76 | -157 | $2,176 | $2,719,233 | 3 | Sony Pictures Releasing | false | false |
| 14 | 7 | 3:10 to Yuma | $123,792 | -76.9% | 106 | -142 | $1,167 | $919,795 | 2 | Medusa Distribuzione | false | false |
| 15 | 13 | The Girl by the Lake | $73,809 | -48% | 20 | -31 | $3,690 | $3,318,512 | 7 | Medusa Distribuzione | false | false |
| 16 | 10 | Hairspray | $54,791 | -76.4% | 24 | -83 | $2,282 | $4,426,195 | 5 | Moviemax | false | false |
| 17 | 32 | Welcome to the Roses 2007 Re-release | $42,744 | +659.6% | 16 | +13 | $2,671 | $95,823 | 2 | Moviemax | false | false |
| 18 | 14 | Death at a Funeral | $42,230 | -60.9% | 14 | -33 | $3,016 | $3,100,495 | 6 | Mikado Film | false | false |
| 19 | 8 | Evan Almighty | $36,527 | -86.6% | 28 | -114 | $1,304 | $5,573,267 | 5 | Universal Pictures International (UPI) | false | false |
| 20 | 16 | It's a Free World... | $33,548 | -59.2% | 16 | -29 | $2,096 | $908,283 | 5 | BIM Distribuzione | false | false |
| 21 | 11 | The Invasion | $32,056 | -83.2% | 10 | -111 | $3,205 | $994,412 | 3 | Warner Bros. | false | false |
| 22 | 12 | Surf's Up | $30,919 | -79.8% | 31 | -133 | $997 | $2,039,708 | 4 | Sony Pictures Releasing | false | false |
| 23 | 17 | Angel | $15,669 | -76.2% | 10 | -36 | $1,566 | $379,091 | 4 | Teodora Film | false | false |
| 24 | 27 | You, the Living | $8,847 | -39% | 7 | -1 | $1,263 | $32,767 | 2 | Lady Film | false | false |
| 25 | 18 | The Simpsons Movie | $7,219 | -87.4% | 12 | -42 | $601 | $23,291,003 | 7 | 20th Century Fox International | false | false |
| 26 | 25 | Piano, solo | $6,476 | -68.1% | 7 | -14 | $925 | $914,332 | 6 | 01 Distribution | false | false |
| 27 | 15 | Mr. Brooks | $6,311 | -93.2% | 10 | -59 | $631 | $1,084,781 | 4 | Walt Disney Pictures | false | false |
| 28 | 23 | Two Days in Paris | $6,253 | -71% | 7 | -10 | $893 | $210,991 | 5 | DNC Entertainment | false | false |
| 29 | 19 | Concrete Romance | $4,662 | -91.3% | 6 | -38 | $777 | $1,285,951 | 4 | 01 Distribution | false | false |
| 30 | 22 | Shrek the Third | $4,603 | -80.1% | 5 | -21 | $920 | $29,083,570 | 9 | Universal Pictures International (UPI) | false | false |
| 31 | 26 | Atonement | $3,586 | -76% | 4 | -11 | $896 | $1,371,852 | 6 | Universal Pictures International (UPI) | false | false |
| 32 | 20 | The Brave One | $3,348 | -92.8% | 5 | -22 | $669 | $2,113,606 | 5 | Warner Bros. | false | false |
| 33 | 35 | Le ragioni dell'aragosta | $3,072 | -22.2% | 5 | -3 | $614 | $614,224 | 8 | Istituto Luce | false | false |
| 34 | 29 | Scream of the Ants | $2,777 | -65.4% | 3 | - | $925 | $166,383 | 7 | BIM Distribuzione | false | false |
| 35 | 21 | Becoming Jane | $2,673 | -91% | 1 | -27 | $2,673 | $187,754 | 3 | Eagle Pictures | false | false |
| 36 | 31 | The Wind Blows Round | $2,449 | -57% | 2 | - | $1,224 | $291,996 | 26 | Aranciafilm | false | false |
| 37 | 37 | The Lives of Others | $2,039 | -7.3% | 1 | - | $2,039 | $5,220,873 | 30 | 01 Distribution | false | false |
| 38 | 33 | Breath | $1,997 | -52.2% | 2 | -3 | $998 | $213,328 | 9 | Mikado Film | false | false |
| 39 | 38 | The Romance of Astrea and Celadon | $1,729 | -10.9% | 2 | -3 | $864 | $216,053 | 9 | BIM Distribuzione | false | false |
| 40 | - | The Reef | $1,564 | - | 3 | - | $521 | $369,052 | 17 | Mediafilm | false | false |
| 41 | - | Arthur and the Invisibles | $1,460 | - | 1 | - | $1,460 | $2,656,590 | 38 | 01 Distribution | false | false |
| 42 | - | Il rabdomante | $1,269 | - | 1 | - | $1,269 | $108,009 | 8 | Independent Films | false | false |
| 43 | 30 | I'm Not There | $1,203 | -80.2% | 2 | -5 | $601 | $955,777 | 8 | BIM Distribuzione | false | false |
| 44 | 43 | Red Like the Sky | $1,032 | +4.5% | 1 | - | $1,032 | $153,374 | 31 | Lady Film | false | false |
| 45 | 34 | Il dolce e l'amaro | $793 | -80.1% | 2 | -2 | $396 | $1,275,105 | 8 | Medusa Distribuzione | false | false |
| 46 | 49 | Prova a volare | $633 | +0.6% | 1 | - | $633 | $452,529 | 10 | Istituto Luce | false | false |
| 47 | - | Gardens in Autumn | $632 | - | 1 | - | $632 | $274,758 | 53 | Mikado Film | false | false |
| 48 | - | Charlotte's Web | $527 | - | 1 | - | $527 | $88,806 | 34 | Universal Pictures International (UPI) | false | false |
| 49 | 50 | 7 km da Gerusalemme | $521 | +0.6% | 1 | - | $521 | $80,509 | 26 | Mediafilm | false | false |
| 50 | 42 | Sweet Sweet Marja | $498 | -56.1% | 1 | -1 | $498 | $79,894 | 14 | Mediaplex | false | false |
| 51 | 39 | No Reservations | $391 | -75.3% | 1 | -2 | $391 | $1,587,445 | 7 | Warner Bros. | false | false |
| 52 | - | Scrivilo sui muri | $361 | - | 1 | - | $361 | $1,349,071 | 6 | Eagle Pictures | false | false |
