| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Game Plan | $230,358 | - | 43 | - | $5,357 | $230,358 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | The Bucket List | $222,727 | -36.9% | 62 | -3 | $3,592 | $694,240 | 2 | Warner Bros. | false | false |
| 3 | - | Sweeney Todd: The Demon Barber of Fleet Street | $217,032 | - | 46 | - | $4,718 | $217,032 | 1 | Warner Bros. | true | false |
| 4 | - | Eastern Promises | $120,531 | - | 43 | - | $2,803 | $120,531 | 1 | Distribution Company | true | false |
| 5 | 2 | Cloverfield | $104,086 | -53.6% | 45 | +5 | $2,313 | $404,239 | 2 | United International Pictures | false | false |
| 6 | - | Juno | $90,551 | - | 41 | - | $2,208 | $90,551 | 1 | Alfa Films | true | false |
| 7 | 5 | Atonement | $70,450 | -54.2% | 43 | +5 | $1,638 | $280,388 | 2 | United International Pictures | false | false |
| 8 | 4 | Explosive Brigade: Pirate Mission | $67,154 | -59.7% | 96 | +9 | $699 | $576,092 | 3 | Argentina Sono Film S.A.C.I. | false | false |
| 9 | 9 | An American Haunting | $58,284 | -40.6% | 39 | +4 | $1,494 | $371,562 | 3 | Distribution Company | false | false |
| 10 | 3 | The Water Horse | $53,777 | -69% | 38 | - | $1,415 | $290,854 | 2 | Sony Pictures Releasing | false | false |
| 11 | 10 | Charlie Wilson's War | $46,355 | -51.4% | 44 | +2 | $1,053 | $741,160 | 4 | United International Pictures | false | false |
| 12 | 7 | 27 Dresses | $44,524 | -61.4% | 53 | +3 | $840 | $206,971 | 2 | 20th Century Fox International | false | false |
| 13 | 6 | National Treasure: Book of Secrets | $41,276 | -67.7% | 70 | -12 | $589 | $1,579,777 | 5 | Walt Disney Pictures | false | false |
| 14 | 8 | Enchanted | $30,698 | -73.2% | 102 | -6 | $300 | $2,721,353 | 7 | Walt Disney Pictures | false | false |
| 15 | 13 | Love in the Time of Cholera | $22,100 | -42.4% | 27 | -1 | $818 | $431,091 | 5 | 20th Century Fox International | false | false |
| 16 | 14 | Aliens vs. Predator: Requiem | $18,223 | -48.5% | 38 | +3 | $479 | $644,343 | 6 | 20th Century Fox International | false | false |
| 17 | 11 | I Am Legend | $17,902 | -67.9% | 42 | -30 | $426 | $2,061,002 | 8 | Warner Bros. | false | false |
| 18 | - | Bratz | $16,799 | - | 27 | - | $622 | $16,799 | 1 | Pachamama Cine | true | false |
| 19 | 12 | Alvin and the Chipmunks | $13,898 | -69.6% | 53 | - | $262 | $748,332 | 7 | 20th Century Fox International | false | false |
| 20 | 18 | Hitman | $8,946 | -20.9% | 17 | +1 | $526 | $152,278 | 4 | 20th Century Fox International | false | false |
| 21 | 19 | Gone Baby Gone | $6,546 | -36.1% | 12 | -1 | $545 | $408,643 | 13 | Walt Disney Pictures | false | false |
| 22 | 15 | American Gangster | $6,414 | -74.3% | 14 | -10 | $458 | $755,857 | 7 | United International Pictures | false | false |
| 23 | 16 | The Heartbreak Kid | $6,312 | -53% | 15 | -4 | $420 | $904,654 | 15 | United International Pictures | false | false |
| 24 | 17 | 1408 | $6,155 | -52.3% | 9 | -5 | $683 | $216,358 | 4 | United International Pictures | false | false |
| 25 | - | The Kite Runner | $5,208 | - | 12 | - | $434 | $5,208 | 1 | United International Pictures | true | false |
| 26 | 24 | Sleuth | $4,617 | +17.6% | 12 | +2 | $384 | $153,957 | 6 | Sony Pictures Releasing | false | false |
| 27 | 22 | Possible Lives | $2,374 | -57.3% | 5 | - | $474 | $9,873 | 2 | Primer Plano Film Group | false | false |
| 28 | 34 | The Assassination of Jesse James by the Coward Robert Ford | $1,929 | +239% | 6 | +2 | $321 | $155,264 | 12 | Warner Bros. | false | false |
| 29 | 23 | The Cave of the Yellow Dog 2008 Re-release | $1,756 | -64.5% | 3 | -1 | $585 | $25,890 | 3 | IFA | false | false |
| 30 | 27 | Giants of Valdes | $1,473 | -20.2% | 6 | +1 | $245 | $80,346 | 5 | Primer Plano Film Group | false | false |
| 31 | 21 | I Do: How to Get Married and Stay Single | $720 | -88.5% | 3 | -4 | $240 | $64,609 | 4 | Alfa Films | false | false |
| 32 | 29 | Bee Movie | $609 | -54.3% | 3 | -4 | $203 | $1,467,502 | 11 | United International Pictures | false | false |
| 33 | 20 | Beowulf | $508 | -93.3% | 3 | +1 | $169 | $705,534 | 13 | Warner Bros. | false | false |
| 34 | 37 | Bordertown | $504 | +96.9% | 1 | -1 | $504 | $59,649 | 5 | Distribution Company | false | false |
| 35 | 31 | Café Lumière 2007 Re-release | $467 | -54% | 2 | - | $233 | $50,735 | 10 | 791 Cine | false | false |
| 36 | 35 | After the Wedding | $379 | +16.6% | 2 | - | $189 | $106,614 | 13 | Alfa Films | false | false |
| 37 | 25 | My Best Friend | $302 | -87.6% | 3 | -2 | $100 | $121,482 | 7 | Alfa Films | false | false |
| 38 | - | August Rush | $274 | - | 1 | - | $274 | $69,916 | 6 | Distribution Company | false | false |
| 39 | 30 | 4 Months, 3 Weeks and 2 Days | $217 | -83.1% | 1 | -1 | $217 | $202,457 | 11 | Pachamama Cine | false | false |
| 40 | 26 | The Golden Compass | $150 | -93.4% | 11 | -1 | $13 | $1,385,916 | 10 | Distribution Company | false | false |
| 41 | - | Spider-Man 3 | $127 | - | 1 | - | $127 | $4,454,153 | 42 | Sony Pictures Releasing | false | false |
| 42 | 38 | Encarnacion | $118 | -29.8% | 3 | +1 | $39 | $40,878 | 19 | Distribution Company | false | false |
| 43 | 41 | Suspiros del corazón | $118 | -1.7% | 1 | - | $118 | $69,795 | 6 | Primer Plano Film Group | false | false |
| 44 | - | Pirates of the Caribbean: At World's End | $117 | - | 1 | - | $117 | $4,889,474 | 39 | Buena Vista International | false | false |
| 45 | - | Ratatouille | $115 | - | 1 | - | $115 | $3,843,055 | 33 | Buena Vista International | false | false |
| 46 | 44 | Lights in the Dusk | $108 | +111.8% | 1 | - | $108 | $51,952 | 21 | Alfa Films | false | false |
| 47 | 28 | I Could Never Be Your Woman | $76 | -95.3% | 1 | -3 | $76 | $293,930 | 7 | CDI Films | false | false |
| 48 | 39 | Miss Potter | $34 | -74.8% | 1 | - | $34 | $15,047 | 3 | United International Pictures | false | false |
| 49 | 40 | Underdog | $13 | -89.2% | 1 | -2 | $13 | $850,692 | 20 | Walt Disney Pictures | false | false |
