| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Nim's Island | $1,707,371 | - | 304 | - | $5,616 | $1,707,371 | 1 | Moviemax | true | false |
| 2 | 1 | The Kite Runner | $1,678,007 | -32.2% | 370 | -1 | $4,535 | $9,600,966 | 3 | Filmauro | false | false |
| 3 | - | Leatherheads | $1,233,973 | - | 218 | - | $5,660 | $1,233,973 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Next | $1,001,052 | -43.8% | 273 | -16 | $3,666 | $3,315,025 | 2 | Medusa Distribuzione | false | false |
| 5 | - | La seconda volta non si scorda mai | $985,503 | - | 217 | - | $4,541 | $997,217 | 1 | Mikado Film | true | false |
| 6 | 3 | Tutta la vita davanti | $695,999 | -47% | 209 | -143 | $3,330 | $4,683,465 | 3 | Medusa Distribuzione | false | false |
| 7 | 5 | Juno | $673,021 | -22.5% | 236 | -3 | $2,851 | $1,914,535 | 2 | 20th Century Fox International | false | false |
| 8 | 4 | Amore, bugie & calcetto | $558,960 | -41% | 269 | -44 | $2,077 | $1,809,606 | 2 | Warner Bros. | false | false |
| 9 | 6 | Non pensarci | $379,355 | -33% | 173 | -49 | $2,192 | $1,181,797 | 2 | 01 Distribution | false | false |
| 10 | - | Shoot 'Em Up | $367,494 | - | 194 | - | $1,894 | $367,494 | 1 | Eagle Pictures | true | false |
| 11 | - | The Oxford Murders | $354,058 | - | 100 | - | $3,540 | $354,058 | 1 | Warner Bros. | true | false |
| 12 | 7 | The Eye | $187,422 | -61.6% | 96 | -81 | $1,952 | $874,934 | 2 | Mediafilm | false | false |
| 13 | 14 | Ci sta un francese, un inglese e un napoletano | $134,860 | -24.6% | 64 | +59 | $2,107 | $641,985 | 3 | Medusa Distribuzione | false | false |
| 14 | 13 | The Fox and the Child | $128,752 | -37.9% | 120 | -66 | $1,072 | $2,180,216 | 4 | Lucky Red | false | false |
| 15 | 9 | The Spiderwick Chronicles | $113,965 | -62.1% | 92 | -86 | $1,238 | $3,395,797 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | - | Good Morning Heartache | $113,405 | - | 79 | - | $1,435 | $113,405 | 1 | Medusa Distribuzione | true | false |
| 17 | - | Shine a Light | $89,232 | - | 7 | - | $12,747 | $89,232 | 1 | BIM Distribuzione | true | false |
| 18 | 8 | 27 Dresses | $73,321 | -76% | 40 | -109 | $1,833 | $3,815,472 | 4 | 20th Century Fox International | false | false |
| 19 | 15 | Before the Devil Knows You're Dead | $70,093 | -55.4% | 30 | -41 | $2,336 | $4,121,911 | 5 | Medusa Distribuzione | false | false |
| 20 | - | Interview | $62,010 | - | 44 | - | $1,409 | $62,010 | 1 | Fandango | true | false |
| 21 | 19 | The Band's Visit | $60,969 | -28.1% | 26 | -17 | $2,344 | $724,068 | 4 | Mikado Film | false | false |
| 22 | 21 | The Zone | $54,744 | +6.1% | 25 | -2 | $2,189 | $134,794 | 2 | Sacher Distribuzione | false | false |
| 23 | 18 | The Water Horse | $52,405 | -42.5% | 81 | -10 | $646 | $1,932,355 | 5 | Sony Pictures Releasing | false | false |
| 24 | 10 | Questa notte è ancora nostra | $42,508 | -85.2% | 46 | -127 | $924 | $4,948,881 | 4 | Walt Disney Pictures | false | false |
| 25 | 11 | 10,000 BC | $39,529 | -85% | 29 | -93 | $1,363 | $8,169,767 | 5 | Warner Bros. | false | false |
| 26 | 17 | My Blueberry Nights | $38,264 | -69.3% | 25 | -66 | $1,530 | $600,882 | 3 | BIM Distribuzione | false | false |
| 27 | 22 | La rabbia | $34,697 | -29.3% | 11 | -3 | $3,154 | $414,784 | 7 | L'Altrofilm | false | false |
| 28 | 12 | Grande, grosso e... Verdone | $28,210 | -87% | 21 | -87 | $1,343 | $20,169,084 | 6 | Filmauro | false | false |
| 29 | 16 | Colpo d'occhio | $25,430 | -82.8% | 20 | -76 | $1,271 | $4,028,292 | 4 | 01 Distribution | false | false |
| 30 | 25 | Into the Wild | $21,612 | -24.4% | 10 | -5 | $2,161 | $7,851,924 | 12 | BIM Distribuzione | false | false |
| 31 | 26 | Persepolis | $20,149 | -25% | 9 | -5 | $2,238 | $1,738,018 | 8 | BIM Distribuzione | false | false |
| 32 | 23 | Gone Baby Gone | $17,472 | -58.1% | 5 | -11 | $3,494 | $77,651 | 2 | Walt Disney Pictures | false | false |
| 33 | 20 | No Country for Old Men | $15,193 | -74.5% | 10 | -25 | $1,519 | $8,888,789 | 8 | Universal Pictures International (UPI) | false | false |
| 34 | 28 | Cover Boy... Last Revolution | $12,700 | -6.5% | 7 | -1 | $1,814 | $102,450 | 4 | Istituto Luce | false | false |
| 35 | 32 | Happily N'Ever After | $9,988 | -6.7% | 13 | -12 | $768 | $1,366,579 | 6 | DNC Entertainment | false | false |
| 36 | 35 | Jimmy della collina | $8,669 | -5% | 4 | - | $2,167 | $23,685 | 2 | Aranciafilm | false | false |
| 37 | - | La seconda volta | $8,540 | - | 1 | - | $8,540 | $1,151,013 | - | Lucky Red | - | false |
| 38 | 36 | Odette Toulemonde | $7,348 | -18.9% | 5 | - | $1,469 | $390,120 | 6 | Warner Bros. | false | false |
| 39 | 33 | The Wind Blows Round | $6,844 | -32.6% | 3 | -12 | $2,281 | $565,411 | 50 | Aranciafilm | false | false |
| 40 | 34 | There Will Be Blood | $6,084 | -40.1% | 6 | -9 | $1,014 | $2,593,500 | 9 | Walt Disney Pictures | false | false |
| 41 | 27 | The Early Bird Catches the Worm | $5,866 | -66.6% | 1 | -8 | $5,866 | $1,435,754 | 7 | Medusa Distribuzione | false | false |
| 42 | - | The Counterfeiters | $5,558 | - | 4 | - | $1,389 | $341,203 | 12 | Lady Film | false | false |
| 43 | 31 | Fallen Heroes | $4,505 | -59% | 3 | -6 | $1,501 | $76,915 | 3 | BIM Distribuzione | false | false |
| 44 | - | L'aria del lago | $4,210 | - | 2 | - | $2,105 | $4,979 | 1 | Independent Films | true | false |
| 45 | 41 | Mr. Magorium's Wonder Emporium | $4,046 | +42.2% | 1 | - | $4,046 | $2,458,274 | 12 | Moviemax | false | false |
| 46 | - | Andres and me | $3,630 | - | 1 | - | $3,630 | $3,630 | 1 | N/A | true | false |
| 47 | 47 | I Viceré | $2,155 | +19.7% | 1 | - | $2,155 | $2,583,925 | 23 | 01 Distribution | false | false |
| 48 | 29 | We Own the Night | $1,914 | -85.7% | 2 | -9 | $957 | $1,230,182 | 5 | BIM Distribuzione | false | false |
| 49 | 38 | Sonetàula | $1,601 | -77% | 2 | -4 | $800 | $283,454 | 6 | Lucky Red | false | false |
| 50 | - | American Gangster | $1,566 | - | 2 | - | $783 | $15,737,765 | 13 | Universal Pictures International (UPI) | false | false |
