| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $493,545 | - | 51 | - | $9,677 | $494,757 | 1 | Warner Bros. | true | false |
| 2 | - | Bedtime Stories | $450,492 | - | 64 | - | $7,038 | $450,492 | 1 | Walt Disney Pictures | true | false |
| 3 | 1 | Bolt | $208,450 | -23.3% | 109 | +6 | $1,912 | $2,094,024 | 4 | Walt Disney Pictures | false | false |
| 4 | - | Vicky Cristina Barcelona | $178,822 | - | 32 | - | $5,588 | $178,822 | 1 | Pachamama Cine | true | false |
| 5 | 3 | Yes Man | $121,964 | -27.1% | 51 | -7 | $2,391 | $1,019,493 | 4 | Warner Bros. | false | false |
| 6 | - | Underworld: Rise of the Lycans | $117,014 | - | 30 | - | $3,900 | $117,014 | 1 | Sony Pictures Releasing | true | false |
| 7 | 2 | Changeling | $113,030 | -32.9% | 44 | -3 | $2,568 | $659,120 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | - | The Tale of Despereaux | $79,731 | - | 50 | - | $1,594 | $79,731 | 1 | United International Pictures | true | false |
| 9 | 5 | Marley & Me | $65,024 | -51.1% | 56 | -3 | $1,161 | $535,804 | 3 | 20th Century Fox International | false | false |
| 10 | 4 | Inkheart | $59,111 | -62.5% | 47 | +1 | $1,257 | $295,887 | 2 | Distribution Company | false | false |
| 11 | 6 | Revolutionary Road | $49,036 | -56.8% | 23 | - | $2,132 | $199,376 | 2 | Paramount Pictures International | false | false |
| 12 | 10 | Australia | $41,958 | -32.4% | 55 | -9 | $762 | $783,470 | 5 | 20th Century Fox International | false | false |
| 13 | 7 | Twilight | $32,955 | -65.2% | 41 | -45 | $803 | $1,847,948 | 6 | Alfa Films | false | false |
| 14 | 8 | Doubt | $25,869 | -61.6% | 25 | -5 | $1,034 | $420,203 | 4 | Walt Disney Pictures | false | false |
| 15 | 11 | Madagascar: Escape 2 Africa | $25,447 | -44.2% | 43 | -20 | $591 | $5,677,569 | 10 | Paramount Pictures International | false | false |
| 16 | 9 | The Day the Earth Stood Still | $19,205 | -70.2% | 30 | -43 | $640 | $2,058,551 | 6 | 20th Century Fox International | false | false |
| 17 | 15 | Bangkok Dangerous | $5,922 | -51.2% | 17 | -14 | $348 | $114,307 | 4 | Distribution Company | false | false |
| 18 | 16 | Emma's Bliss | $5,484 | -45.4% | 5 | - | $1,096 | $19,714 | 2 | Primer Plano Film Group | false | false |
| 19 | 18 | The Duchess | $4,317 | -47.8% | 8 | -6 | $539 | $258,300 | 9 | United International Pictures | false | false |
| 20 | 14 | El ratón Pérez 2 | $3,560 | -75.8% | 17 | -34 | $209 | $712,475 | 6 | Walt Disney Pictures | false | false |
| 21 | 19 | Blame it on Fidel | $3,395 | -53.5% | 2 | -5 | $1,697 | $28,937 | 3 | Zeta Films | false | false |
| 22 | 23 | Body of Lies | $2,827 | -23.8% | 8 | -3 | $353 | $922,323 | 11 | Warner Bros. | false | false |
| 23 | 24 | Righteous Kill | $2,669 | -20.9% | 5 | -3 | $533 | $578,880 | 12 | CDI Films | false | false |
| 24 | 26 | Late Bloomers | $2,518 | +16.6% | 7 | +2 | $359 | $79,195 | 11 | Primer Plano Film Group | false | false |
| 25 | 17 | Rudo y Cursi | $2,124 | -76.6% | 8 | -18 | $265 | $308,882 | 5 | United International Pictures | false | false |
| 26 | 22 | Four Christmases | $1,798 | -54.3% | 5 | -8 | $359 | $419,775 | 8 | Distribution Company | false | false |
| 27 | 12 | The Spirit | $1,766 | -92.8% | 3 | -23 | $588 | $99,604 | 3 | Sony Pictures Releasing | false | false |
| 28 | 42 | Fly Me to the Moon 3D | $1,347 | +608.9% | 4 | +2 | $336 | $131,799 | 8 | Distribution Company | false | false |
| 29 | 27 | RocknRolla | $979 | -53.9% | 7 | -6 | $139 | $90,710 | 9 | Warner Bros. | false | false |
| 30 | 28 | Deception | $968 | -51.6% | 3 | -1 | $322 | $68,763 | 9 | Alfa Films | false | false |
| 31 | 25 | Quarantine | $881 | -63.6% | 3 | -5 | $293 | $376,330 | 10 | Sony Pictures Releasing | false | false |
| 32 | 39 | Fados | $872 | +292.8% | 3 | +2 | $290 | $36,437 | 11 | Distribution Company | false | false |
| 33 | 20 | W. | $811 | -88.3% | 5 | -5 | $162 | $65,768 | 4 | Impacto Cine | false | false |
| 34 | 30 | Che: Part One | $782 | -41.2% | 2 | -1 | $391 | $668,455 | 13 | Alfa Films | false | false |
| 35 | 29 | Aniceto | $651 | -54.6% | 2 | -2 | $325 | $138,043 | 35 | Primer Plano Film Group | false | false |
| 36 | 21 | The Boy in the Striped Pajamas | $585 | -89.1% | 2 | -7 | $292 | $86,726 | 10 | Walt Disney Pictures | false | false |
| 37 | 31 | High School Musical 3: Senior Year | $458 | -60.5% | 3 | -8 | $152 | $1,313,043 | 11 | Walt Disney Pictures | false | false |
| 38 | 36 | Manual of Love 2008 Re-release | $396 | +20.4% | 1 | -1 | $396 | $136,772 | 20 | Notro Films | false | false |
| 39 | 45 | The Camera Obscura 2008 Re-release | $361 | +173.5% | 1 | - | $361 | $65,300 | 17 | Distribution Company | false | false |
| 40 | 33 | Planet Terror | $345 | -50.5% | 1 | -5 | $345 | $93,790 | 9 | Pachamama Cine | false | false |
| 41 | 46 | La próxima estación | $329 | +178.8% | 1 | - | $329 | $122,994 | 23 | Primer Plano Film Group | false | false |
| 42 | 32 | Tear This Heart Out | $278 | -67.7% | 2 | -2 | $139 | $57,217 | 11 | 20th Century Fox International | false | false |
| 43 | 34 | The Pope's Toilet | $201 | -71.1% | 1 | -3 | $201 | $28,519 | 6 | Primer Plano Film Group | false | false |
| 44 | 50 | Café de los maestros | $170 | +183.3% | 1 | - | $170 | $96,882 | 33 | Alfa Films | false | false |
| 45 | 51 | Two Friends and a Burglar | $147 | +250% | 1 | - | $147 | $10,148 | 11 | Primer Plano Film Group | false | false |
| 46 | 37 | Death Sentence | $130 | -51.1% | 2 | -1 | $65 | $187,600 | 10 | Distribution Company | false | false |
| 47 | 38 | The Tracker 2008 Re-release | $126 | -48.1% | 1 | - | $126 | $47,887 | 7 | IFA | false | false |
| 48 | 43 | Burn After Reading | $115 | -22.8% | 1 | - | $115 | $849,840 | 16 | United International Pictures | false | false |
| 49 | - | El último bandoneón | $112 | - | 1 | - | $112 | $4,871 | 121 | Primer Plano Film Group | false | false |
| 50 | 52 | Saw V | $104 | +300% | 1 | -1 | $104 | $1,049,431 | 15 | Walt Disney Pictures | false | false |
| 51 | 48 | Shara | $104 | +20.9% | 1 | - | $104 | $44,065 | 15 | Zeta Films | false | false |
| 52 | 41 | Bella | $58 | -71.8% | 1 | - | $58 | $31,323 | 7 | CDI Films | false | false |
| 53 | 49 | Mamma Mia! | $52 | -29.7% | 1 | - | $52 | $1,441,898 | 25 | United International Pictures | false | false |
| 54 | 40 | Asterix at the Olympic Games | $34 | -84.1% | 1 | -1 | $34 | $47,752 | 5 | Distribution Company | false | false |
| 55 | 47 | Beverly Hills Chihuahua | $29 | -72.1% | 1 | -3 | $29 | $1,559,399 | 18 | Walt Disney Pictures | false | false |
| 56 | - | Eagle Eye | $27 | - | 1 | - | $27 | $195,906 | 20 | United International Pictures | false | false |
