| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $7,763,481 | - | 506 | - | $15,342 | $9,188,295 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Star Trek | $5,261,414 | -41.9% | 498 | -1 | $10,565 | $18,374,034 | 2 | Paramount Pictures International | false | false |
| 3 | 2 | Coraline | $2,082,902 | -43.6% | 394 | +2 | $5,286 | $6,391,784 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | X-Men Origins: Wolverine | $1,837,930 | -45.8% | 452 | -32 | $4,066 | $21,639,077 | 3 | 20th Century Fox International | false | false |
| 5 | 4 | Hannah Montana: The Movie | $1,518,831 | -23.5% | 424 | +8 | $3,582 | $9,142,974 | 3 | Walt Disney Pictures | false | false |
| 6 | - | Fighting | $1,504,181 | - | 293 | - | $5,133 | $1,504,181 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 5 | Ghosts of Girlfriends Past | $725,967 | -39.4% | 336 | -46 | $2,160 | $5,358,634 | 3 | Entertainment Film Distributors | false | false |
| 8 | 6 | State of Play | $426,990 | -52.1% | 292 | -89 | $1,462 | $7,859,124 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Monsters vs. Aliens | $387,639 | -9.5% | 354 | -28 | $1,095 | $31,525,794 | 7 | Paramount Pictures International | false | false |
| 10 | 7 | 17 Again | $210,013 | -52.3% | 254 | -76 | $826 | $16,798,171 | 6 | Entertainment Film Distributors | false | false |
| 11 | - | Synecdoche, New York | $186,850 | - | 30 | - | $6,228 | $186,850 | 1 | Revolver Entertainment | true | false |
| 12 | 9 | I Love You, Man | $158,226 | -50.9% | 105 | -65 | $1,506 | $5,963,838 | 5 | Paramount Pictures International | false | false |
| 13 | 12 | In the Loop | $125,301 | -24.8% | 63 | -8 | $1,988 | $2,907,433 | 5 | Optimum Releasing | false | false |
| 14 | 11 | Chéri | $90,508 | -50.6% | 76 | -5 | $1,190 | $414,139 | 2 | Warner Bros. | false | false |
| 15 | 10 | Fast & Furious | $63,906 | -78.3% | 109 | -166 | $586 | $20,546,785 | 6 | Universal Pictures International (UPI) | false | false |
| 16 | 16 | Munde U.K. De | $45,602 | -10% | 7 | +1 | $6,514 | $125,521 | 2 | - | false | false |
| 17 | - | Let the Right One In | $32,255 | - | 24 | - | $1,343 | $1,518,488 | 6 | Momentum Pictures | false | false |
| 18 | 14 | Is Anybody There? | $29,263 | -64.9% | 32 | -40 | $914 | $548,087 | 3 | Optimum Releasing | false | false |
| 19 | 13 | The Uninvited | $27,997 | -73.7% | 35 | -57 | $799 | $1,487,818 | 4 | Paramount Pictures International | false | false |
| 20 | - | Race to Witch Mountain | $26,163 | - | 77 | - | $339 | $3,804,706 | 6 | Walt Disney Pictures | false | false |
| 21 | - | Hotel for Dogs | $23,656 | - | 96 | - | $246 | $10,814,090 | 14 | Paramount Pictures International | false | false |
| 22 | - | Sarvam | $16,903 | - | 7 | - | $2,414 | $16,903 | 1 | Ayngaran International | true | false |
| 23 | - | Encounters at the End of the World | $15,235 | - | 6 | - | $2,539 | $181,053 | 4 | Revolver Entertainment | false | false |
| 24 | - | Paul Blart: Mall Cop | $14,459 | - | 26 | - | $556 | $7,732,094 | 9 | Sony Pictures Releasing | false | false |
| 25 | 17 | The Boat That Rocked | $12,962 | -60.8% | 14 | -25 | $925 | $9,242,903 | 7 | Universal Pictures International (UPI) | false | false |
| 26 | - | Gran Torino | $9,694 | - | 11 | - | $881 | $12,656,039 | 13 | Warner Bros. | false | false |
| 27 | 18 | O'Horten | $9,042 | -38.2% | 7 | -2 | $1,291 | $33,767 | 2 | Artificial Eye | false | false |
| 28 | - | Under the Sea 3D | $6,843 | - | 1 | - | $6,843 | $287,416 | 14 | IMAX | false | false |
| 29 | 21 | Fifty Dead Men Walking | $6,497 | -46.3% | 9 | -9 | $721 | $575,684 | 6 | - | false | false |
| 30 | - | Knowing | $6,388 | - | 15 | - | $425 | $10,342,959 | 8 | Entertainment One | false | false |
| 31 | 19 | The Damned United | $5,573 | -56.3% | 8 | -15 | $696 | $3,272,144 | 8 | Sony Pictures Releasing | false | false |
| 32 | - | Marley & Me | $4,888 | - | 8 | - | $611 | $23,286,860 | 10 | 20th Century Fox International | false | false |
| 33 | 22 | The Young Victoria | $4,818 | -55.8% | 6 | -2 | $803 | $7,441,788 | 11 | Momentum Pictures | false | false |
| 34 | - | Duplicity | $4,756 | - | 7 | - | $679 | $4,383,941 | 9 | Universal Pictures International (UPI) | false | false |
| 35 | 23 | Shifty | $4,307 | -50.9% | 5 | -7 | $861 | $208,307 | 4 | - | false | false |
| 36 | 20 | Sounds Like Teen Spirit | $4,011 | -67% | 7 | -1 | $573 | $22,204 | 2 | - | false | false |
| 37 | 25 | Slumdog Millionaire | $3,888 | -39.1% | 4 | -4 | $972 | $47,999,373 | 19 | Pathé | false | false |
| 38 | - | French Film | $3,161 | - | 3 | - | $1,053 | $3,161 | 1 | Vertigo Films | true | false |
| 39 | 24 | Little Ashes | $2,947 | -60.4% | 1 | -3 | $2,947 | $14,522 | 2 | N/A | false | false |
| 40 | - | The Class | $2,825 | - | 4 | - | $706 | $1,309,838 | 12 | Artificial Eye | false | false |
| 41 | - | Observe and Report | $2,592 | - | 6 | - | $432 | $1,025,086 | 4 | Warner Bros. | false | false |
| 42 | - | Crank: High Voltage | $2,469 | - | 8 | - | $308 | $1,859,343 | 5 | Lionsgate | false | false |
| 43 | - | Watchmen | $1,988 | - | 3 | - | $662 | $13,610,059 | 11 | Paramount Pictures International | false | false |
| 44 | 32 | Good | $1,888 | +71.3% | 5 | +3 | $377 | $82,905 | 5 | Lionsgate | false | false |
| 45 | 29 | The Age of Stupid | $989 | -61.7% | 3 | -2 | $329 | $278,681 | 9 | Periscoop Film | false | false |
