| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $13,843,415 | - | 513 | - | $26,985 | $13,843,415 | 1 | Paramount Pictures International | true | false |
| 2 | - | The Hangover | $3,709,760 | - | 428 | - | $8,667 | $12,724,730 | - | Warner Bros. | - | false |
| 3 | 3 | Night at the Museum: Battle of the Smithsonian | $1,347,373 | -24.4% | 481 | -25 | $2,801 | $30,159,922 | 5 | 20th Century Fox International | false | false |
| 4 | 2 | Terminator Salvation | $1,325,561 | -58.7% | 456 | -28 | $2,906 | $21,053,270 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | Angels & Demons | $583,524 | -31% | 323 | -61 | $1,806 | $29,581,596 | 6 | Sony Pictures Releasing | false | false |
| 6 | 4 | Drag Me to Hell | $454,185 | -48.3% | 316 | -69 | $1,437 | $9,804,393 | 4 | Lionsgate | false | false |
| 7 | 6 | Star Trek | $395,602 | -40.6% | 282 | -92 | $1,402 | $34,466,567 | 7 | Paramount Pictures International | false | false |
| 8 | 8 | Looking for Eric | $354,813 | -41.1% | 225 | -14 | $1,576 | $1,393,463 | 2 | Entertainment Film Distributors | false | false |
| 9 | 7 | The Last House on the Left | $312,334 | -51.6% | 285 | -19 | $1,095 | $1,452,272 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Last Chance Harvey | $263,066 | -39.4% | 242 | -67 | $1,087 | $2,917,311 | 3 | Momentum Pictures | false | false |
| 11 | 10 | Coraline | $210,901 | -20.6% | 295 | -73 | $714 | $11,792,131 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | Hannah Montana: The Movie | $152,782 | -23.8% | 327 | -53 | $467 | $13,512,562 | 8 | Walt Disney Pictures | false | false |
| 13 | 11 | Red Cliff | $88,907 | -64.7% | 133 | -56 | $668 | $519,422 | 2 | Entertainment Film Distributors | false | false |
| 14 | - | Katyn | $41,419 | - | 12 | - | $3,451 | $41,419 | 1 | Artificial Eye | true | false |
| 15 | - | Telstar: The Joe Meek Story | $36,843 | - | 33 | - | $1,116 | $36,843 | 1 | N/A | true | false |
| 16 | 14 | Anything for Her | $35,590 | -42.4% | 23 | -15 | $1,547 | $375,915 | 3 | - | false | false |
| 17 | 19 | Synecdoche, New York | $17,743 | -8.8% | 15 | +1 | $1,182 | $803,745 | 6 | Revolver Entertainment | false | false |
| 18 | - | North by Northwest 2009 Re-release | $13,909 | - | 2 | - | $6,954 | $13,909 | 1 | British Film Institute (BFI) | true | false |
| 19 | 20 | Monsters vs. Aliens | $13,843 | -27.6% | 60 | -18 | $230 | $34,857,374 | 12 | Paramount Pictures International | false | false |
| 20 | 13 | Doghouse | $12,969 | -86% | 47 | -52 | $275 | $179,836 | 2 | Vertigo Films | false | false |
| 21 | 16 | Obsessed | $11,777 | -70.2% | 17 | -47 | $692 | $842,077 | 4 | Sony Pictures Releasing | false | false |
| 22 | 21 | State of Play | $11,091 | -31.2% | 12 | -6 | $924 | $9,199,311 | 9 | Universal Pictures International (UPI) | false | false |
| 23 | 22 | In the Loop | $9,935 | -35.9% | 8 | -8 | $1,241 | $3,487,763 | 10 | Optimum Releasing | false | false |
| 24 | 26 | Sleep Furiously | $9,495 | +6.4% | 12 | +2 | $791 | $96,918 | 4 | New Wave Films | false | false |
| 25 | 17 | X-Men Origins: Wolverine | $9,444 | -73.2% | 32 | -63 | $295 | $26,826,667 | 8 | 20th Century Fox International | false | false |
| 26 | 23 | I Love You, Man | $9,274 | -34.5% | 6 | -10 | $1,545 | $6,838,762 | 10 | Paramount Pictures International | false | false |
| 27 | 24 | Ghosts of Girlfriends Past | $8,146 | -32.8% | 10 | -7 | $814 | $6,859,122 | 8 | Entertainment Film Distributors | false | false |
| 28 | 34 | A Girl Cut in Two | $7,899 | +66.5% | 7 | +3 | $1,128 | $96,725 | 5 | Artificial Eye | false | false |
| 29 | - | Gigantic | $7,254 | - | 8 | - | $906 | $7,254 | - | The Works UK Distribution | - | false |
| 30 | 30 | 17 Again | $6,917 | +15.8% | 12 | - | $576 | $18,531,480 | 11 | Entertainment Film Distributors | false | false |
| 31 | - | Kal Kissne Dekha | $6,886 | - | 6 | - | $1,147 | $29,423 | 2 | - | false | false |
| 32 | 41 | Is Anybody There? | $4,995 | +186.6% | 11 | -1 | $454 | $723,768 | 8 | Optimum Releasing | false | false |
| 33 | 18 | 12 Rounds | $4,533 | -79.5% | 18 | -56 | $251 | $1,187,641 | 4 | 20th Century Fox International | false | false |
| 34 | 36 | Fermat's Room 2009 Re-release | $4,418 | +10.1% | 4 | -1 | $1,104 | $33,133 | 4 | Revolver Entertainment | false | false |
| 35 | - | Mark of an Angel | $4,312 | - | 6 | - | $718 | $125,091 | 5 | - | false | false |
| 36 | 33 | Everlasting Moments | $3,875 | -21.2% | 5 | - | $775 | $88,649 | 5 | Icon Film Distribution | false | false |
| 37 | 31 | Munde U.K. De | $3,821 | -34.1% | 3 | - | $1,273 | $304,000 | 7 | - | false | false |
| 38 | 29 | Chéri | $3,778 | -39.8% | 10 | -10 | $377 | $660,283 | 7 | Warner Bros. | false | false |
| 39 | 28 | Let the Right One In | $3,367 | -51.5% | 3 | -2 | $1,122 | $1,764,796 | 11 | Momentum Pictures | false | false |
| 40 | - | The Class | $2,998 | - | 2 | - | $1,499 | $1,439,964 | 17 | Artificial Eye | false | false |
| 41 | 15 | The End of the Line | $2,670 | -95.1% | 2 | -3 | $1,335 | $68,867 | 2 | Periscoop Film | false | false |
| 42 | - | Fugitive Pieces | $2,642 | - | 4 | - | $660 | $14,330 | 4 | Soda Pictures | false | false |
| 43 | 39 | Sugar | $2,500 | -13% | 6 | +2 | $416 | $26,807 | 3 | Axiom Films | false | false |
| 44 | - | Fireflies in the Garden 2008 Re-release | $2,388 | - | 7 | - | $341 | $89,687 | 4 | The Works UK Distribution | false | false |
| 45 | 27 | Fighting | $1,763 | -78.5% | 11 | -15 | $160 | $3,341,473 | 6 | Universal Pictures International (UPI) | false | false |
| 46 | 37 | New Town Killers | $1,370 | -58.2% | 1 | -7 | $1,370 | $7,262 | 2 | N/A | false | false |
| 47 | 35 | Gran Torino | $1,184 | -72.7% | 1 | -6 | $1,184 | $13,739,813 | 18 | Warner Bros. | false | false |
| 48 | - | Helen | $1,108 | - | 4 | - | $277 | $34,820 | 8 | New Wave Films | false | false |
| 49 | - | The Disappeared | $966 | - | 1 | - | $966 | $966 | 1 | ICA Films | true | false |
| 50 | - | O'Horten | $495 | - | 1 | - | $495 | $70,678 | 7 | Artificial Eye | false | false |
| 51 | 38 | The Boat That Rocked | $460 | -85.4% | 1 | -3 | $460 | $10,125,727 | 12 | Universal Pictures International (UPI) | false | false |
| 52 | 48 | Awaydays | $392 | -11.1% | 2 | - | $196 | $129,802 | 5 | Optimum Releasing | false | false |
| 53 | - | The Young Victoria | $384 | - | 1 | - | $384 | $8,129,988 | 16 | Momentum Pictures | false | false |
| 54 | 40 | Shadows in the Sun | $259 | -88.3% | 1 | - | $259 | $8,227 | 3 | Artificial Eye | false | false |
| 55 | 46 | Fifty Dead Men Walking | $211 | -64.2% | 3 | - | $70 | $639,729 | 11 | - | false | false |
| 56 | - | Slumdog Millionaire | $206 | - | 1 | - | $206 | $52,213,042 | 24 | Pathé | false | false |
