| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ice Age: Dawn of the Dinosaurs | $12,474,502 | - | 526 | - | $23,715 | $12,474,502 | 1 | 20th Century Fox International | true | false |
| 2 | - | Public Enemies | $3,638,383 | - | 458 | - | $7,944 | $3,638,383 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Transformers: Revenge of the Fallen | $3,615,873 | -49.9% | 491 | -30 | $7,364 | $33,938,100 | 3 | Paramount Pictures International | false | false |
| 4 | - | The Hangover | $2,488,988 | - | 409 | - | $6,085 | $22,832,612 | - | Warner Bros. | - | false |
| 5 | 4 | My Sister's Keeper | $1,244,303 | -18.4% | 353 | -2 | $3,524 | $4,097,466 | 2 | Entertainment Film Distributors | false | false |
| 6 | 3 | Year One | $799,856 | -50.5% | 380 | -2 | $2,104 | $3,283,154 | 3 | Sony Pictures Releasing | false | false |
| 7 | - | Kambakkht Ishq | $489,081 | - | 56 | - | $8,733 | $489,081 | 1 | Eros Worldwide | true | false |
| 8 | 5 | Night at the Museum: Battle of the Smithsonian | $245,678 | -69.8% | 487 | +31 | $504 | $31,483,931 | 7 | 20th Century Fox International | false | false |
| 9 | 6 | Terminator Salvation | $244,911 | -65.1% | 232 | -161 | $1,055 | $22,739,695 | 5 | Sony Pictures Releasing | false | false |
| 10 | 10 | Sunshine Cleaning | $88,296 | -57.5% | 71 | -33 | $1,243 | $421,160 | 2 | N/A | false | false |
| 11 | 7 | Blood: The Last Vampire | $87,298 | -77.2% | 167 | -102 | $522 | $719,542 | 4 | Warner Bros. | false | false |
| 12 | 8 | Angels & Demons | $85,902 | -68.7% | 80 | -116 | $1,073 | $30,085,471 | 8 | Sony Pictures Releasing | false | false |
| 13 | 9 | New York | $85,844 | -67% | 32 | -2 | $2,682 | $490,167 | 2 | Yash Raj Films | false | false |
| 14 | 13 | Looking for Eric | $51,083 | -56.8% | 61 | -60 | $837 | $1,827,743 | 4 | Entertainment Film Distributors | false | false |
| 15 | 12 | Star Trek | $46,120 | -70.7% | 55 | -91 | $838 | $34,596,320 | 9 | Paramount Pictures International | false | false |
| 16 | 15 | Hannah Montana: The Movie | $45,871 | -51.2% | 147 | -97 | $312 | $13,577,815 | 10 | Walt Disney Pictures | false | false |
| 17 | 11 | Drag Me to Hell | $43,839 | -76% | 70 | -103 | $626 | $10,287,672 | 6 | Lionsgate | false | false |
| 18 | 17 | Rudo y Cursi | $32,437 | -58.8% | 28 | -7 | $1,158 | $153,853 | 2 | Optimum Releasing | false | false |
| 19 | 19 | Katyn | $17,412 | -22.7% | 15 | +2 | $1,160 | $133,104 | 3 | Artificial Eye | false | false |
| 20 | 16 | The Last House on the Left | $16,971 | -79.7% | 30 | -96 | $565 | $1,826,417 | 4 | Universal Pictures International (UPI) | false | false |
| 21 | 14 | Coraline | $14,788 | -87.3% | 63 | -162 | $234 | $11,867,760 | 9 | Universal Pictures International (UPI) | false | false |
| 22 | 18 | Last Chance Harvey | $12,292 | -83.4% | 24 | -91 | $512 | $3,224,793 | 5 | Momentum Pictures | false | false |
| 23 | 24 | Synecdoche, New York | $7,168 | -25.8% | 9 | -2 | $796 | $832,193 | 8 | Revolver Entertainment | false | false |
| 24 | 20 | Red Cliff | $7,008 | -62.6% | 10 | -9 | $700 | $613,110 | 4 | Entertainment Film Distributors | false | false |
| 25 | 21 | Anything for Her | $6,448 | -47.3% | 8 | -5 | $806 | $418,239 | 5 | - | false | false |
| 26 | 23 | Monsters vs. Aliens | $4,729 | -51.5% | 37 | -16 | $127 | $34,536,526 | 14 | Paramount Pictures International | false | false |
| 27 | 26 | In the Loop | $4,116 | -44.2% | 7 | - | $588 | $3,477,461 | 12 | Optimum Releasing | false | false |
| 28 | - | Strawberry & Chocolate 2009 Re-release | $3,382 | - | 1 | - | $3,382 | $3,382 | 1 | N/A | true | false |
| 29 | 25 | Telstar: The Joe Meek Story | $3,320 | -63.7% | 3 | -10 | $1,106 | $86,521 | 3 | N/A | false | false |
| 30 | 27 | State of Play | $3,251 | -51.3% | 6 | -2 | $541 | $9,130,346 | 11 | Universal Pictures International (UPI) | false | false |
| 31 | 39 | A Girl Cut in Two | $2,771 | +11.5% | 2 | -2 | $1,385 | $108,814 | 7 | Artificial Eye | false | false |
| 32 | 34 | Is Anybody There? | $2,617 | -25.4% | 2 | -3 | $1,308 | $741,606 | 10 | Optimum Releasing | false | false |
| 33 | 32 | Everlasting Moments | $2,557 | -32.9% | 4 | -2 | $639 | $101,530 | 7 | Icon Film Distribution | false | false |
| 34 | 36 | Lake Tahoe | $2,309 | -27.5% | 2 | - | $1,154 | $7,096 | 2 | - | false | false |
| 35 | 48 | Gigantic | $2,123 | +112.5% | 4 | +1 | $530 | $15,902 | 2 | The Works UK Distribution | false | false |
| 36 | 28 | Shirin | $2,054 | -68.3% | 1 | -1 | $2,054 | $11,941 | 2 | British Film Institute (BFI) | false | false |
| 37 | 35 | Let the Right One In | $1,997 | -41.4% | 3 | +1 | $665 | $1,758,848 | 13 | Momentum Pictures | false | false |
| 38 | 31 | 17 Again | $1,848 | -58% | 6 | -4 | $308 | $18,363,139 | 13 | Entertainment Film Distributors | false | false |
| 39 | - | Sugar | $1,564 | - | 1 | - | $1,564 | $30,000 | 5 | Axiom Films | false | false |
| 40 | 45 | Fireflies in the Garden 2008 Re-release | $1,452 | +12.3% | 7 | +4 | $207 | $94,902 | 6 | The Works UK Distribution | false | false |
| 41 | 29 | North by Northwest 2009 Re-release | $1,412 | -76.8% | 1 | - | $1,412 | $32,674 | 3 | British Film Institute (BFI) | false | false |
| 42 | - | S. Darko | $1,269 | - | 9 | - | $141 | $1,269 | 1 | Lionsgate | true | false |
| 43 | 40 | Fermat's Room 2009 Re-release | $1,182 | -46.9% | 1 | -3 | $1,182 | $42,194 | 6 | Revolver Entertainment | false | false |
| 44 | 46 | Mark of an Angel | $1,065 | -10.1% | 4 | - | $266 | $130,793 | 7 | - | false | false |
| 45 | 41 | Munde U.K. De | $1,065 | -49.2% | 1 | -1 | $1,065 | $307,106 | 9 | - | false | false |
| 46 | - | Fugitive Pieces | $921 | - | 4 | - | $230 | $19,545 | 6 | Soda Pictures | false | false |
| 47 | 22 | On Her Majesty's Secret Service 2009 Re-release | $784 | -92.1% | 1 | -31 | $784 | $13,392 | 2 | Park Circus | false | false |
| 48 | 43 | Sleep Furiously | $774 | -57.2% | 4 | +1 | $193 | $106,148 | 6 | New Wave Films | false | false |
| 49 | - | In the City of Sylvia | $748 | - | 1 | - | $748 | $124,659 | 17 | Axiom Films | false | false |
| 50 | 44 | The Class | $702 | -57% | 2 | - | $351 | $1,433,912 | 19 | Artificial Eye | false | false |
| 51 | 47 | The Young Victoria | $665 | -38.7% | 2 | +1 | $332 | $8,053,651 | 18 | Momentum Pictures | false | false |
| 52 | 49 | New Town Killers | $612 | -38.7% | 3 | +1 | $204 | $9,603 | 4 | N/A | false | false |
| 53 | - | Am I Black Enough for You | $594 | - | 2 | - | $297 | $594 | 1 | Verve Pictures | true | false |
| 54 | 42 | Chéri | $521 | -71.3% | 3 | -4 | $173 | $665,574 | 9 | Warner Bros. | false | false |
| 55 | 53 | Shadows in the Sun | $491 | +43.6% | 2 | +1 | $245 | $9,761 | 5 | Artificial Eye | false | false |
| 56 | 37 | The End of the Line | $451 | -85.7% | 3 | -2 | $150 | $76,685 | 4 | Periscoop Film | false | false |
