| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $242,336 | -69.3% | 87 | - | $2,785 | $1,194,763 | 2 | NuMetro Distribution | false | false |
| 2 | 3 | The Proposal | $205,552 | -24.9% | 65 | - | $3,162 | $1,299,853 | 3 | Ster-Kinekor Pictures | false | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $184,280 | -43% | 89 | -4 | $2,070 | $2,854,063 | 4 | NuMetro Distribution | false | false |
| 4 | 5 | The Hangover | $87,234 | -14.6% | 55 | +2 | $1,586 | $1,400,305 | 6 | NuMetro Distribution | false | false |
| 5 | 4 | Transformers: Revenge of the Fallen | $78,873 | -36.5% | 78 | -9 | $1,011 | $2,189,031 | 5 | United International Pictures | false | false |
| 6 | - | Fighting | $58,326 | - | 30 | - | $1,944 | $58,326 | 1 | United International Pictures | true | false |
| 7 | 6 | Knowing | $44,697 | -41.8% | 63 | -9 | $709 | $681,301 | 4 | United International Pictures | false | false |
| 8 | 7 | Brüno | $39,492 | -40.8% | 38 | -5 | $1,039 | $313,451 | 3 | United International Pictures | false | false |
| 9 | 8 | The Haunting in Connecticut | $19,624 | -40.8% | 25 | - | $784 | $65,653 | 2 | NuMetro Distribution | false | false |
| 10 | - | Management | $17,270 | - | 10 | - | $1,727 | $17,270 | 1 | NuMetro Distribution | true | false |
| 11 | - | I Love You, Beth Cooper | $12,901 | - | 10 | - | $1,290 | $12,901 | 1 | NuMetro Distribution | true | false |
| 12 | 10 | Obsessed | $10,060 | -37.6% | 15 | -3 | $670 | $278,547 | 6 | Ster-Kinekor Pictures | false | false |
| 13 | 9 | Night at the Museum: Battle of the Smithsonian | $9,665 | -62% | 25 | -11 | $386 | $1,710,703 | 10 | NuMetro Distribution | false | false |
| 14 | 11 | Crossing Over | $9,616 | -37.7% | 10 | - | $961 | $32,803 | 2 | Ster-Kinekor Pictures | false | false |
| 15 | 16 | State of Play | $4,560 | -14.2% | 9 | -4 | $506 | $335,556 | 7 | United International Pictures | false | false |
| 16 | 18 | The Song of Sparrows | $3,686 | -24.2% | 3 | - | $1,228 | $20,711 | 3 | Ster-Kinekor Pictures | false | false |
| 17 | 17 | Welcome to the Sticks | $3,593 | -27.4% | 4 | - | $898 | $43,533 | 5 | Ster-Kinekor Pictures | false | false |
| 18 | - | Luck | $3,441 | - | 3 | - | $1,147 | $3,441 | 1 | Ster-Kinekor Pictures | true | false |
| 19 | 15 | The Brothers Bloom | $3,153 | -42.3% | 7 | -2 | $450 | $48,591 | 4 | Ster-Kinekor Pictures | false | false |
| 20 | 20 | The Burning Plain | $2,455 | -15.4% | 8 | - | $306 | $90,078 | 8 | United International Pictures | false | false |
| 21 | 14 | Duplicity | $2,444 | -71.2% | 9 | -6 | $271 | $660,584 | 9 | United International Pictures | false | false |
| 22 | - | Man on Wire | $1,544 | - | 2 | - | $772 | $48,167 | 11 | Ster-Kinekor Pictures | false | false |
| 23 | 21 | Sunshine Cleaning | $1,274 | -54.5% | 3 | -2 | $424 | $87,684 | 7 | United International Pictures | false | false |
