| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $599,453 | -46.2% | 607 | -206 | $987 | $24,158,559 | 4 | Warner Bros. | false | false |
| 2 | 2 | The Hangover | $188,051 | -2.1% | 134 | -8 | $1,403 | $4,873,537 | 8 | Warner Bros. | false | false |
| 3 | 3 | Ghosts of Girlfriends Past | $146,551 | -5.3% | 123 | -25 | $1,191 | $2,420,405 | 6 | Warner Bros. | false | false |
| 4 | 4 | Transformers: Revenge of the Fallen | $117,574 | -21.7% | 148 | -24 | $794 | $11,324,074 | 7 | United International Pictures | false | false |
| 5 | 6 | Outlander | $60,798 | -14.1% | 76 | -25 | $799 | $1,540,485 | 6 | Eagle Pictures | false | false |
| 6 | 5 | Coraline | $58,537 | -18.3% | 65 | -9 | $900 | $4,739,148 | 8 | United International Pictures | false | false |
| 7 | 10 | Journey to the Center of the Earth | $40,980 | +37% | 34 | +9 | $1,205 | $11,516,159 | 30 | 01 Distribution | false | false |
| 8 | 8 | The Girl with the Dragon Tattoo | $39,155 | +13.3% | 44 | +3 | $889 | $5,093,637 | 11 | BIM Distribuzione | false | false |
| 9 | 7 | The Boat That Rocked | $33,481 | -12.2% | 35 | -6 | $956 | $1,015,467 | 9 | United International Pictures | false | false |
| 10 | 9 | Un'estate ai Caraibi | $30,261 | -1.2% | 49 | -8 | $617 | $5,187,440 | 9 | Medusa Distribuzione | false | false |
| 11 | - | Flash of Genius | $29,776 | - | 52 | - | $572 | $29,776 | 1 | United International Pictures | true | false |
| 12 | 14 | Angels & Demons | $29,133 | +44.9% | 14 | - | $2,080 | $26,146,922 | 13 | Sony Pictures Releasing | false | false |
| 13 | - | I Know Who Killed Me | $25,141 | - | 21 | - | $1,197 | $103,274 | 49 | Moviemax | false | false |
| 14 | 18 | Gran Torino | $21,573 | +46.4% | 30 | +2 | $719 | $13,015,744 | 22 | Warner Bros. | false | false |
| 15 | - | My Bloody Valentine | $18,700 | - | 23 | - | $813 | $8,718,118 | 14 | Medusa Distribuzione | false | false |
| 16 | 11 | Imagine That | $14,891 | -35.6% | 12 | - | $1,240 | $52,130 | 2 | United International Pictures | false | false |
| 17 | 13 | Killshot | $13,905 | -31.1% | 10 | -2 | $1,390 | $47,375 | 2 | 01 Distribution | false | false |
| 18 | 16 | Ultimate Heist | $11,442 | -30.7% | 3 | - | $3,814 | $37,047 | 2 | Medusa Distribuzione | false | false |
| 19 | 19 | Towelhead | $10,201 | -24% | 16 | -4 | $637 | $91,273 | 4 | N/A | false | false |
| 20 | 24 | My Best Friend's Girl | $9,688 | -9.6% | 16 | -4 | $605 | $1,525,304 | 8 | Eagle Pictures | false | false |
| 21 | 21 | State of Play | $9,617 | -11.7% | 9 | +1 | $1,068 | $3,533,804 | 15 | United International Pictures | false | false |
| 22 | 17 | Notorious | $9,179 | -42% | 20 | -21 | $458 | $209,043 | 4 | 20th Century Fox International | false | false |
| 23 | 15 | Baby Mama | $9,130 | -47.9% | 30 | -34 | $304 | $117,506 | 3 | United International Pictures | false | false |
| 24 | 23 | Night at the Museum: Battle of the Smithsonian | $7,117 | -34% | 14 | -4 | $508 | $9,949,785 | 12 | 20th Century Fox International | false | false |
| 25 | - | Tutta la vita davanti | $6,716 | - | 23 | - | $292 | $5,648,340 | 72 | Medusa Distribuzione | false | false |
| 26 | 33 | Adventureland | $6,708 | +14.6% | 13 | +6 | $516 | $31,944 | 5 | Walt Disney Pictures | false | false |
| 27 | 26 | We Can Do That | $6,584 | -29.2% | 6 | -3 | $1,097 | $2,770,961 | 41 | Warner Bros. | false | false |
| 28 | 28 | Obsessed | $6,532 | -26.2% | 6 | -2 | $1,088 | $69,847 | 4 | Sony Pictures Releasing | false | false |
| 29 | 30 | The Visitor | $5,755 | -19.8% | 10 | +3 | $575 | $2,194,531 | 36 | Bolero Film | false | false |
| 30 | 25 | 12 Rounds | $5,624 | -44% | 6 | -4 | $937 | $21,424 | 6 | 20th Century Fox International | false | false |
| 31 | 29 | Ghost Town | $5,500 | -32.9% | 16 | -3 | $343 | $96,482 | 4 | United International Pictures | false | false |
| 32 | - | The Wave | $4,946 | - | 9 | - | $549 | $698,890 | 24 | BIM Distribuzione | false | false |
| 33 | - | Two Lovers | $4,794 | - | 4 | - | $1,198 | $1,327,671 | 20 | BIM Distribuzione | false | false |
| 34 | - | Ex | $4,743 | - | 11 | - | $431 | $15,340,865 | 27 | 01 Distribution | false | false |
