| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Secret in Their Eyes | $749,964 | - | 66 | - | $11,363 | $979,103 | 1 | Distribution Company | true | false |
| 2 | 4 | Dad for a Day | $282,022 | -21% | 75 | - | $3,760 | $816,228 | 2 | Walt Disney Pictures | false | false |
| 3 | 3 | G-Force | $277,635 | -23.4% | 113 | +3 | $2,456 | $1,524,038 | 3 | Walt Disney Pictures | false | false |
| 4 | 1 | Harry Potter and the Half-Blood Prince | $228,762 | -38.8% | 143 | +33 | $1,599 | $4,213,965 | 4 | Warner Bros. | false | false |
| 5 | 2 | Ice Age: Dawn of the Dinosaurs | $227,841 | -38.2% | 108 | -35 | $2,109 | $7,511,715 | 7 | 20th Century Fox International | false | false |
| 6 | - | The Hangover | $189,749 | - | 41 | - | $4,628 | $242,506 | 1 | Warner Bros. | true | false |
| 7 | - | Hannah Montana: The Movie | $160,368 | - | 67 | - | $2,393 | $211,807 | 1 | Walt Disney Pictures | true | false |
| 8 | - | Drag Me to Hell | $136,093 | - | 36 | - | $3,780 | $174,721 | 1 | Universal Pictures International (UPI) | true | false |
| 9 | 5 | Public Enemies | $121,728 | -38.2% | 51 | +1 | $2,386 | $817,620 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 6 | G.I. Joe: The Rise of Cobra | $82,260 | -56.1% | 67 | - | $1,227 | $352,333 | 2 | Paramount Pictures International | false | false |
| 11 | 7 | The Taking of Pelham 123 | $37,190 | -45.8% | 43 | -2 | $864 | $906,938 | 5 | Sony Pictures Releasing | false | false |
| 12 | 9 | My Sister's Keeper | $24,477 | -60.5% | 24 | - | $1,019 | $112,206 | 2 | Distribution Company | false | false |
| 13 | 8 | Defiance | $18,296 | -70.7% | 23 | -6 | $795 | $99,379 | 2 | N/A | false | false |
| 14 | 10 | The Proposal | $13,177 | -55.7% | 22 | -17 | $598 | $872,697 | 7 | Walt Disney Pictures | false | false |
| 15 | 12 | The Secret of the Grain | $12,882 | -24.8% | 7 | +1 | $1,840 | $59,069 | 3 | N/A | false | false |
| 16 | 11 | Transformers: Revenge of the Fallen | $6,787 | -71.5% | 9 | -19 | $754 | $2,387,654 | 8 | Paramount Pictures International | false | false |
| 17 | 15 | I've Loved You So Long | $6,738 | -35.4% | 6 | -1 | $1,123 | $189,825 | 5 | Alfa Films | false | false |
| 18 | 14 | Too Much Romance... It's Time for Stuffed Peppers | $5,800 | -46.5% | 5 | - | $1,160 | $22,312 | 2 | Primer Plano Film Group | false | false |
| 19 | 16 | Days and Clouds | $4,119 | -57.2% | 4 | -1 | $1,029 | $85,995 | 4 | Impacto Cine | false | false |
| 20 | 13 | Solstice | $3,033 | -79.2% | 7 | -15 | $433 | $268,844 | 6 | Distribution Company | false | false |
| 21 | 19 | State of Play | $3,025 | -48.7% | 6 | -9 | $504 | $524,163 | 10 | Universal Pictures International (UPI) | false | false |
| 22 | 20 | Felicitas | $2,615 | -35.3% | 5 | -3 | $523 | $444,850 | 10 | Pachamama Cine | false | false |
| 23 | 18 | Up | $1,910 | -69.1% | 8 | -19 | $238 | $3,427,607 | 10 | Walt Disney Pictures | false | false |
| 24 | 17 | 100% lucha, el amo de los clones | $1,677 | -82% | 14 | -27 | $119 | $281,681 | 5 | Primer Plano Film Group | false | false |
| 25 | - | Ponyo | $1,373 | - | 3 | - | $457 | $59,312 | 4 | Pachamama Cine | false | false |
| 26 | 23 | Home | $1,210 | -45.9% | 2 | - | $605 | $23,544 | 4 | Primer Plano Film Group | false | false |
| 27 | 21 | Last Chance Harvey | $1,042 | -68.9% | 2 | -6 | $521 | $468,450 | 11 | Distribution Company | false | false |
| 28 | 30 | Katyn | $1,028 | +153.2% | 3 | +2 | $342 | $20,246 | 5 | N/A | false | false |
| 29 | 24 | The Unborn | $635 | -29.2% | 1 | -1 | $635 | $775,747 | 13 | Universal Pictures International (UPI) | false | false |
| 30 | 28 | All the Lonely People | $410 | -4.9% | 3 | -1 | $136 | $17,966 | 9 | Primer Plano Film Group | false | false |
| 31 | 26 | A Christmas Tale | $348 | -37.6% | 2 | - | $174 | $82,564 | 7 | Pachamama Cine | false | false |
| 32 | 29 | The Secrets | $307 | -24.9% | 2 | - | $153 | $12,093 | 5 | Distribution Company | false | false |
| 33 | 31 | Final Image | $265 | -31.7% | 1 | - | $265 | $956 | 2 | N/A | false | false |
| 34 | 22 | Breath 2009 Re-release | $214 | -92.7% | 1 | -4 | $214 | $19,059 | 3 | Distribution Company | false | false |
| 35 | 25 | Che: Part Two | $167 | -72.3% | 1 | -2 | $167 | $52,754 | 9 | Alfa Films | false | false |
| 36 | 37 | The Reader | $136 | +61.9% | 2 | +1 | $68 | $572,173 | 15 | Pachamama Cine | false | false |
| 37 | 35 | Pride and Glory | $129 | -43.2% | 2 | - | $64 | $131,976 | 8 | Distribution Company | false | false |
| 38 | 34 | Inspector Bellamy | $120 | -55.1% | 1 | - | $120 | $139,804 | 11 | Alfa Films | false | false |
| 39 | 27 | Some Place Nowhere | $107 | -77.1% | 2 | -1 | $53 | $804 | 2 | N/A | false | false |
| 40 | 36 | Lorna's Silence | $16 | -83.8% | 1 | -1 | $16 | $91,043 | 14 | Distribution Company | false | false |
| 41 | 38 | Night at the Museum: Battle of the Smithsonian | $8 | -78.4% | 2 | +1 | $4 | $2,537,860 | 13 | 20th Century Fox International | false | false |
