| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Public Enemies | $1,621,699 | -34.9% | 460 | - | $3,525 | $5,708,743 | 2 | United International Pictures | false | false |
| 2 | 3 | The Hangover | $1,242,066 | -20.3% | 327 | +9 | $3,798 | $3,877,833 | 2 | Warner Bros. | false | false |
| 3 | 2 | Up | $905,574 | -57.3% | 409 | -161 | $2,214 | $23,725,933 | 4 | Walt Disney Pictures | false | false |
| 4 | 4 | Aliens in the Attic | $658,913 | -26.9% | 324 | - | $2,033 | $2,396,141 | 2 | 20th Century Fox International | false | false |
| 5 | - | Ong Bak 2 | $513,171 | - | 181 | - | $2,835 | $526,142 | 1 | - | true | false |
| 6 | 5 | G.I. Joe: The Rise of Cobra | $441,178 | -42.6% | 394 | -63 | $1,119 | $5,709,728 | 3 | Paramount Pictures International | false | false |
| 7 | 6 | The Taking of Pelham 123 | $316,854 | -18.1% | 293 | -48 | $1,081 | $8,123,772 | 5 | Sony Pictures Releasing | false | false |
| 8 | 7 | The Haunting in Connecticut | $252,379 | -27.5% | 244 | -9 | $1,034 | $2,062,792 | 3 | DeAPlaneta | false | false |
| 9 | - | Antichrist | $215,157 | - | 80 | - | $2,689 | $215,157 | 1 | Golem Distribución | true | false |
| 10 | - | Land of the Lost | $196,382 | - | 95 | - | $2,067 | $196,382 | 1 | United International Pictures | true | false |
| 11 | 9 | My Life in Ruins | $173,937 | -19.2% | 194 | -13 | $896 | $1,498,968 | 3 | Manga Entertainment | false | false |
| 12 | 12 | The Girl with the Dragon Tattoo | $149,688 | +11.1% | 127 | +4 | $1,178 | $12,096,857 | 13 | Vértigo Films | false | false |
| 13 | 11 | Drag Me to Hell | $148,663 | -28.3% | 203 | -62 | $732 | $3,501,098 | 4 | United International Pictures | false | false |
| 14 | 8 | Ice Age: Dawn of the Dinosaurs | $142,449 | -35.6% | 235 | -44 | $606 | $30,382,052 | 8 | 20th Century Fox International | false | false |
| 15 | 10 | Harry Potter and the Half-Blood Prince | $139,364 | -33.6% | 261 | -66 | $533 | $19,688,150 | 6 | Warner Bros. | false | false |
| 16 | 13 | The Proposal | $60,705 | -19.1% | 101 | -27 | $601 | $5,654,945 | 7 | Walt Disney Pictures | false | false |
| 17 | - | The Life Before Her Eyes | $48,135 | - | 25 | - | $1,925 | $5,654,945 | 1 | Manga Entertainment | true | false |
| 18 | 14 | Ex | $40,072 | +6.6% | 50 | +6 | $801 | $923,179 | 5 | Notro Films | false | false |
| 19 | 27 | Angels & Demons | $10,866 | +23.2% | 21 | +4 | $517 | $21,905,987 | 15 | Sony Pictures Releasing | false | false |
| 20 | 30 | Brüno | $6,274 | -12% | 6 | -6 | $1,045 | $2,518,798 | 7 | Sony Pictures Releasing | false | false |
| 21 | 48 | Obsessed | $295 | -53.2% | 1 | - | $295 | $1,906,857 | 10 | Sony Pictures Releasing | false | false |
