| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | District 9 | $184,864 | -31.7% | 81 | - | $2,282 | $604,733 | 2 | Ster-Kinekor Pictures | false | false |
| 2 | - | Public Enemies | $98,218 | - | 63 | - | $1,559 | $98,218 | 1 | United International Pictures | true | false |
| 3 | 2 | G.I. Joe: The Rise of Cobra | $89,306 | -20.8% | 73 | - | $1,223 | $904,800 | 4 | United International Pictures | false | false |
| 4 | 3 | G-Force | $80,242 | -15.1% | 62 | -2 | $1,294 | $1,046,916 | 6 | Ster-Kinekor Pictures | false | false |
| 5 | 4 | The Proposal | $68,046 | -11.3% | 62 | -1 | $1,097 | $2,340,544 | 9 | Ster-Kinekor Pictures | false | false |
| 6 | 5 | My Sister's Keeper | $60,357 | -15.2% | 46 | - | $1,312 | $555,031 | 4 | NuMetro Distribution | false | false |
| 7 | 7 | Year One | $25,892 | -15.1% | 19 | -2 | $1,362 | $132,827 | 3 | Ster-Kinekor Pictures | false | false |
| 8 | 8 | Coco Before Chanel | $20,234 | -33% | 9 | - | $2,248 | $66,040 | 2 | NuMetro Distribution | false | false |
| 9 | 6 | The Hangover | $19,518 | -36.4% | 33 | -14 | $591 | $1,922,721 | 12 | NuMetro Distribution | false | false |
| 10 | 10 | Fired Up! | $18,787 | -27% | 26 | -5 | $722 | $264,774 | 5 | Ster-Kinekor Pictures | false | false |
| 11 | 12 | My Life in Ruins | $18,522 | -6.7% | 28 | -3 | $661 | $349,124 | 6 | Ster-Kinekor Pictures | false | false |
| 12 | 9 | Ice Age: Dawn of the Dinosaurs | $16,766 | -36.2% | 32 | -15 | $523 | $3,409,620 | 10 | NuMetro Distribution | false | false |
| 13 | 13 | Not Easily Broken | $13,448 | -28.3% | 19 | -1 | $707 | $79,020 | 3 | NuMetro Distribution | false | false |
| 14 | 11 | Orphan | $12,399 | -39.2% | 19 | -6 | $652 | $82,712 | 3 | NuMetro Distribution | false | false |
| 15 | 14 | Harry Potter and the Half-Blood Prince | $9,162 | -49.7% | 23 | -16 | $398 | $1,764,007 | 8 | NuMetro Distribution | false | false |
| 16 | - | Adam | $9,029 | - | 9 | - | $1,003 | $9,029 | 1 | NuMetro Distribution | true | false |
| 17 | 15 | Fighting | $5,389 | -39.3% | 20 | -1 | $269 | $247,042 | 7 | United International Pictures | false | false |
| 18 | 16 | Disgrace | $4,712 | -19.2% | 9 | -1 | $523 | $51,132 | 4 | United International Pictures | false | false |
| 19 | 19 | A Summer in Genoa | $3,908 | +2.4% | 8 | - | $488 | $56,790 | 5 | United International Pictures | false | false |
| 20 | 18 | Obsessed | $3,440 | -9.9% | 8 | - | $430 | $343,932 | 12 | Ster-Kinekor Pictures | false | false |
| 21 | 17 | Izulu lami | $2,440 | -46.5% | 5 | -12 | $488 | $29,453 | 3 | Ster-Kinekor Pictures | false | false |
| 22 | 21 | Transformers: Revenge of the Fallen | $2,379 | -37.3% | 3 | -3 | $793 | $2,430,504 | 11 | United International Pictures | false | false |
| 23 | 22 | Knowing | $2,278 | -25.4% | 6 | +2 | $379 | $857,229 | 10 | United International Pictures | false | false |
