| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | OceanWorld | $41,890 | - | 4 | - | $10,472 | $41,890 | 1 | ACME | true | false |
| 2 | - | Surrogates | $32,265 | - | 6 | - | $5,377 | $32,265 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | G-Force | $27,286 | -33% | 12 | +1 | $2,273 | $226,920 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | The Ugly Truth | $13,900 | -16.8% | 7 | +3 | $1,985 | $181,323 | 5 | Sony Pictures Releasing | false | false |
| 5 | 3 | Orphan | $8,372 | -37.4% | 7 | - | $1,196 | $62,713 | 3 | - | false | false |
| 6 | 4 | Jennifer's Body | $7,878 | -39% | 5 | - | $1,575 | $27,007 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 5 | Fame | $7,152 | -44.6% | 6 | - | $1,192 | $26,007 | 2 | ACME | false | false |
| 8 | 6 | 9 | $5,845 | -48.8% | 3 | - | $1,948 | $21,193 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | - | Julie & Julia | $4,734 | - | 2 | - | $2,367 | $6,850 | 1 | Sony Pictures Releasing | true | false |
| 10 | 8 | Up | $4,692 | -41.2% | 6 | -2 | $782 | $419,793 | 8 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Inglourious Basterds | $3,304 | -24.5% | 5 | +1 | $660 | $169,355 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | 7 | The Final Destination | $2,922 | -66.9% | 6 | - | $487 | $206,970 | 6 | - | false | false |
| 13 | 9 | Pandorum | $1,811 | -70.7% | 4 | - | $452 | $28,124 | 3 | ACME | false | false |
| 14 | 11 | High Security Vacation | $1,614 | -26.2% | 3 | - | $538 | $68,358 | 6 | ACME | false | false |
| 15 | 12 | Two Lovers | $1,464 | -30.9% | 1 | - | $1,464 | $4,793 | 2 | ACME | false | false |
| 16 | 13 | Vortex | $1,382 | -8.5% | 3 | - | $460 | $39,725 | 18 | N/A | false | false |
| 17 | 15 | Whatever Works | $1,325 | +10.9% | 1 | - | $1,325 | $9,689 | 4 | ACME | false | false |
| 18 | 16 | Mid-August Lunch | $1,323 | +31.1% | 1 | - | $1,323 | $6,613 | 2 | N/A | false | false |
| 19 | 14 | Diary of a Nymphomaniac | $497 | -58.7% | 1 | - | $497 | $41,115 | 10 | ACME | false | false |
| 20 | 17 | Ice Age: Dawn of the Dinosaurs | $320 | -26.1% | 1 | - | $320 | $1,416,044 | 15 | Universal Pictures International (UPI) | false | false |
| 21 | 19 | My Sister's Keeper | $279 | -19.6% | 3 | -1 | $93 | $116,665 | 10 | - | false | false |
