| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $533,781 | +37.6% | 96 | +20 | $5,560 | $7,332,720 | 6 | 20th Century Fox International | false | false |
| 2 | - | Sherlock Holmes | $315,893 | - | 63 | - | $5,014 | $315,893 | 1 | Warner Bros. | true | false |
| 3 | 2 | Tooth Fairy | $68,496 | -1.2% | 36 | +8 | $1,902 | $383,184 | 3 | 20th Century Fox International | false | false |
| 4 | - | Astro Boy | $57,806 | - | 27 | - | $2,140 | $57,806 | 1 | N/A | true | false |
| 5 | - | Saw VI | $53,265 | - | 27 | - | $1,972 | $53,265 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | The Princess and the Frog | $28,762 | -12.8% | 26 | +5 | $1,106 | $901,201 | 8 | Walt Disney Pictures | false | false |
| 7 | 7 | Broken Embraces | $24,532 | +19.8% | 14 | +2 | $1,752 | $65,501 | 2 | United International Pictures | false | false |
| 8 | 3 | Paranormal Activity | $21,334 | -46.2% | 23 | -4 | $927 | $656,889 | 5 | N/A | false | false |
| 9 | 6 | Old Dogs | $18,979 | -22.3% | 18 | -1 | $1,054 | $343,720 | 5 | Walt Disney Pictures | false | false |
| 10 | 8 | The Haunting in Connecticut | $15,943 | -16.3% | 13 | +4 | $1,226 | $56,727 | 2 | Transeuropa | false | false |
| 11 | 5 | Surrogates | $13,900 | -50.8% | 19 | -4 | $731 | $158,472 | 3 | Walt Disney Pictures | false | false |
| 12 | - | An Education | $10,873 | - | 5 | - | $2,174 | $10,873 | 1 | Sony Pictures Releasing | true | false |
| 13 | 9 | Did You Hear About the Morgans? | $5,869 | -61.2% | 13 | -14 | $451 | $89,854 | 3 | Sony Pictures Releasing | false | false |
| 14 | 10 | Cirque du Freak: The Vampire's Assistant | $3,030 | -71.1% | 10 | -7 | $303 | $83,211 | 3 | United International Pictures | false | false |
| 15 | 15 | Planet 51 | $1,265 | -23.1% | 11 | -5 | $115 | $272,410 | 9 | N/A | false | false |
| 16 | 11 | 9 | $1,094 | -82.5% | 4 | -11 | $273 | $101,329 | 4 | N/A | false | false |
| 17 | 16 | The Twilight Saga: New Moon | $1,068 | +2.7% | 3 | -1 | $356 | $2,478,502 | 9 | N/A | false | false |
| 18 | 12 | 2012 | $723 | -75.4% | 1 | -6 | $723 | $4,107,761 | 11 | Sony Pictures Releasing | false | false |
| 19 | 14 | Zombieland | $443 | -79.1% | 2 | -6 | $221 | $79,956 | 4 | Sony Pictures Releasing | false | false |
| 20 | 13 | Happy-Go-Lucky | $2 | -99.9% | 1 | - | $2 | $66,723 | 7 | N/A | false | false |
