| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | How to Train Your Dragon | $44,337 | +75.1% | 10 | - | $4,433 | $121,964 | 2 | Paramount Pictures International | false | false |
| 2 | 1 | Alice in Wonderland | $40,270 | +28.9% | 10 | -1 | $4,027 | $425,501 | 5 | Walt Disney Pictures | false | false |
| 3 | 4 | La despedida | $21,026 | +19.7% | 5 | - | $4,205 | $53,551 | 2 | N/A | false | false |
| 4 | 3 | The Bounty Hunter | $19,499 | +2% | 5 | - | $3,899 | $56,671 | 2 | Sony Pictures Releasing | false | false |
| 5 | 5 | The Book of Eli | $15,682 | +2.2% | 5 | - | $3,136 | $74,380 | 3 | Sony Pictures Releasing | false | false |
| 6 | - | Everybody's Fine | $12,151 | - | 5 | - | $2,430 | $12,151 | 1 | Walt Disney Pictures | true | false |
| 7 | 8 | Edge of Darkness | $8,118 | +24.7% | 3 | - | $2,706 | $110,016 | 6 | Warner Bros. | false | false |
| 8 | - | The Imaginarium of Doctor Parnassus | $6,848 | - | 3 | - | $2,282 | $6,848 | 1 | Sony Pictures Releasing | true | false |
| 9 | 6 | The Blind Side | $6,806 | -5% | 4 | - | $1,701 | $64,641 | 5 | Warner Bros. | false | false |
| 10 | 19 | Tooth Fairy | $5,030 | +208.8% | 4 | - | $1,257 | $68,770 | 6 | 20th Century Fox International | false | false |
| 11 | 9 | Saw VI | $4,754 | -23.6% | 3 | -2 | $1,584 | $16,529 | 2 | Walt Disney Pictures | false | false |
| 12 | 7 | Avatar | $4,337 | -33.5% | 2 | -1 | $2,168 | $1,189,726 | 16 | 20th Century Fox International | false | false |
| 13 | 11 | Amelia | $3,963 | -6.8% | 2 | - | $1,981 | $10,509 | 2 | 20th Century Fox International | false | false |
| 14 | 10 | The Widows of Thursdays | $3,607 | -20.9% | 4 | +1 | $901 | $62,879 | 5 | N/A | false | false |
| 15 | 13 | Let it Rain | $2,176 | -12.3% | 2 | - | $1,088 | $9,880 | 3 | N/A | false | false |
| 16 | 15 | The Hurt Locker | $2,103 | -12.6% | 2 | - | $1,051 | $87,242 | 9 | N/A | false | false |
| 17 | 14 | Two Lovers | $1,394 | -43.5% | 1 | -1 | $1,394 | $13,963 | 3 | N/A | false | false |
| 18 | 17 | An Education | $1,190 | -40% | 1 | -1 | $1,190 | $59,325 | 7 | Sony Pictures Releasing | false | false |
| 19 | 16 | Did You Hear About the Morgans? | $1,028 | -55.8% | 2 | -1 | $514 | $76,495 | 6 | Sony Pictures Releasing | false | false |
| 20 | 12 | Couples Retreat | $947 | -71.5% | 1 | -2 | $947 | $32,124 | 4 | Universal Pictures International (UPI) | false | false |
| 21 | 18 | A Serious Man | $609 | -65.5% | 1 | - | $609 | $23,787 | 6 | Universal Pictures International (UPI) | false | false |
| 22 | 21 | Alvin and the Chipmunks: The Squeakquel | $438 | +86.4% | 1 | - | $438 | $173,471 | 14 | 20th Century Fox International | false | false |
| 23 | 20 | Igor | $340 | -67.1% | 3 | - | $113 | $3,725 | 2 | N/A | false | false |
| 24 | 22 | Cirque du Freak: The Vampire's Assistant | $250 | +142.7% | 2 | - | $125 | $4,159 | 3 | Universal Pictures International (UPI) | false | false |
