| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $762,034 | -37.8% | 102 | -2 | $7,470 | $2,345,429 | 2 | Warner Bros. | false | false |
| 2 | 25 | Brothers | $181,526 | +7,018.7% | 67 | +56 | $2,709 | $1,493,242 | 5 | Distribution Company | false | false |
| 3 | 2 | Brother and Sister | $181,526 | -28.9% | 67 | +3 | $2,709 | $1,493,242 | 4 | Primer Plano Film Group | false | false |
| 4 | 3 | Alice in Wonderland | $128,547 | -20.5% | 89 | -4 | $1,444 | $7,827,366 | 8 | Walt Disney Pictures | false | false |
| 5 | 4 | How to Train Your Dragon | $102,555 | -11.4% | 102 | -7 | $1,005 | $1,614,329 | 5 | Paramount Pictures International | false | false |
| 6 | - | The Men Who Stare at Goats | $81,469 | - | 30 | - | $2,715 | $81,469 | 1 | Sony Pictures Releasing | true | false |
| 7 | - | The White Ribbon | $57,559 | - | 15 | - | $3,837 | $57,559 | 1 | N/A | true | false |
| 8 | 7 | Shutter Island | $55,077 | -15.3% | 43 | +2 | $1,280 | $1,486,097 | 7 | Paramount Pictures International | false | false |
| 9 | 6 | Date Night | $50,760 | -29.1% | 41 | -3 | $1,238 | $307,652 | 3 | 20th Century Fox International | false | false |
| 10 | - | A Single Man | $46,399 | - | 13 | - | $3,569 | $46,399 | 1 | N/A | true | false |
| 11 | - | It's Alive | $42,729 | - | 21 | - | $2,034 | $42,729 | 1 | Distribution Company | true | false |
| 12 | 9 | Remember Me | $39,362 | -4.3% | 28 | +1 | $1,405 | $193,659 | 3 | Alfa Films | false | false |
| 13 | 5 | Love Happens | $38,500 | -48.1% | 33 | +1 | $1,166 | $127,081 | 2 | Distribution Company | false | false |
| 14 | 8 | Case 39 | $36,613 | -28.4% | 30 | -2 | $1,220 | $212,243 | 3 | Paramount Pictures International | false | false |
| 15 | - | The Ex | $36,566 | - | 19 | - | $1,924 | $36,566 | 1 | N/A | true | false |
| 16 | - | Ex | $36,566 | - | 19 | - | $1,924 | $36,566 | 1 | Primer Plano Film Group | true | false |
| 17 | 10 | Dear John | $20,022 | -45% | 25 | -5 | $800 | $63,870 | 2 | Sony Pictures Releasing | false | false |
| 18 | 11 | The Box | $15,940 | -49% | 18 | +1 | $885 | $55,165 | 2 | Alfa Films | false | false |
| 19 | 22 | The Fourth Kind | $14,608 | +284.2% | 15 | +5 | $973 | $152,954 | 4 | Alfa Films | false | false |
| 20 | 16 | Seraphine | $12,491 | -6% | 11 | +5 | $1,135 | $89,598 | 4 | N/A | false | false |
| 21 | 12 | The Bounty Hunter | $12,263 | -45% | 23 | -6 | $533 | $321,804 | 4 | Sony Pictures Releasing | false | false |
| 22 | 13 | The Blind Side | $10,338 | -35.7% | 27 | -3 | $382 | $291,517 | 6 | Warner Bros. | false | false |
| 23 | 14 | The Book of Eli | $8,351 | -44.7% | 25 | -11 | $334 | $580,037 | 6 | Sony Pictures Releasing | false | false |
| 24 | 20 | Everybody's Fine | $7,710 | +52.1% | 16 | +4 | $481 | $184,728 | 6 | Walt Disney Pictures | false | false |
| 25 | 17 | Avatar | $7,037 | -34.7% | 2 | -1 | $3,518 | $13,421,498 | 17 | 20th Century Fox International | false | false |
| 26 | 18 | The Rebound | $6,836 | -21.1% | 11 | +1 | $621 | $118,363 | 5 | Alfa Films | false | false |
| 27 | 19 | Edge of Darkness | $3,245 | -55.7% | 10 | -5 | $324 | $1,139,211 | 9 | Warner Bros. | false | false |
| 28 | 28 | Precious | $2,851 | +63.7% | 9 | +1 | $316 | $298,844 | 11 | N/A | false | false |
| 29 | 15 | Remembering the Children | $2,597 | -81% | 8 | -2 | $324 | $52,134 | 3 | Distribution Company | false | false |
| 30 | 29 | Bad Lieutenant: Port of Call New Orleans | $1,843 | +8.4% | 4 | -2 | $460 | $174,543 | 8 | Distribution Company | false | false |
| 31 | - | Alvin and the Chipmunks: The Squeakquel | $1,575 | - | 2 | - | $787 | $1,089,874 | 14 | 20th Century Fox International | false | false |
| 32 | 21 | Couples Retreat | $1,573 | -60.2% | 5 | -2 | $314 | $162,417 | 8 | Universal Pictures International (UPI) | false | false |
| 33 | 27 | Paco | $1,348 | -30% | 6 | -7 | $224 | $180,443 | 6 | Primer Plano Film Group | false | false |
| 34 | 38 | Fame | $1,257 | +200% | 4 | +2 | $314 | $57,120 | 4 | Impacto Cine | false | false |
| 35 | 37 | 9 | $1,255 | +135% | 7 | +2 | $179 | $38,098 | 6 | Distribution Company | false | false |
| 36 | 26 | Crazy Heart | $911 | -56.1% | 6 | +1 | $151 | $106,699 | 7 | 20th Century Fox International | false | false |
| 37 | 43 | The Princess and the Frog | $785 | +2,080.6% | 4 | +3 | $196 | $1,922,032 | 16 | Walt Disney Pictures | false | false |
| 38 | 44 | Percy Jackson & the Olympians: The Lightning Thief | $616 | +1,711.8% | 3 | +2 | $205 | $724,087 | 10 | 20th Century Fox International | false | false |
| 39 | 30 | The Hurt Locker | $552 | -65.4% | 3 | -10 | $184 | $790,888 | 12 | Distribution Company | false | false |
| 40 | 24 | Coco 2010 Re-release | $266 | -90% | 2 | -6 | $133 | $17,216 | 5 | Impacto Cine | false | false |
| 41 | 34 | A Serious Man | $251 | -69.6% | 3 | +2 | $83 | $149,243 | 9 | Universal Pictures International (UPI) | false | false |
| 42 | 40 | Valentine's Day | $126 | -62.6% | 1 | -2 | $126 | $885,179 | 11 | Warner Bros. | false | false |
| 43 | 39 | Our Beloved Month of August | $107 | -71.2% | 2 | -1 | $53 | $39,783 | 8 | N/A | false | false |
| 44 | 36 | The Wolfman | $103 | -82.7% | 1 | -3 | $103 | $1,121,282 | 11 | Universal Pictures International (UPI) | false | false |
| 45 | 42 | Astro Boy | $84 | +71.4% | 1 | - | $84 | $174,495 | 13 | Alfa Films | false | false |
| 46 | 35 | Old Dogs | $40 | -93.9% | 1 | -2 | $40 | $1,509,067 | 14 | Walt Disney Pictures | false | false |
| 47 | 31 | Birds of Paradise | $13 | -98.8% | 1 | - | $13 | $193,909 | 10 | Sony Pictures Releasing | false | false |
