| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Grown Ups | $357,926 | +4.1% | 59 | +6 | $6,066 | $824,815 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | The American | $284,237 | - | 31 | - | $9,168 | $308,369 | 1 | Benelux Film Distributors | true | false |
| 3 | 3 | Inception | $227,889 | -2.9% | 102 | - | $2,234 | $8,261,253 | 9 | Warner Bros. | false | false |
| 4 | - | Devil | $208,105 | - | 40 | - | $5,202 | $209,839 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 2 | The Last Airbender | $195,983 | -19.4% | 83 | -3 | $2,361 | $3,228,586 | 5 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | Going the Distance | $189,099 | -5% | 70 | - | $2,701 | $506,546 | 2 | Warner Bros. | false | false |
| 7 | 4 | Machete | $175,162 | -25.2% | 51 | - | $3,434 | $530,459 | 2 | Entertainment One | false | false |
| 8 | 6 | Step Up 3D | $173,074 | -12.7% | 88 | -3 | $1,966 | $4,413,437 | 7 | Independent Films | false | false |
| 9 | 7 | Piranha 3D | $136,809 | -27.9% | 58 | +3 | $2,358 | $781,375 | 3 | A-Film Distribution | false | false |
| 10 | 8 | The Expendables | $114,088 | -26.2% | 87 | -5 | $1,311 | $2,396,995 | 5 | Benelux Film Distributors | false | false |
| 11 | 9 | Marmaduke | $110,182 | +20.2% | 82 | -1 | $1,343 | $1,418,967 | 6 | Warner Bros. | false | false |
| 12 | 12 | A Turtle's Tale: Sammy's Adventures | $85,724 | +15.7% | 87 | -1 | $985 | $1,595,519 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | Toy Story 3 | $80,887 | +12.2% | 109 | - | $742 | $5,685,635 | 13 | Walt Disney Pictures | false | false |
| 14 | 10 | Salt | $76,362 | -16.1% | 68 | -7 | $1,122 | $2,881,006 | 7 | Sony Pictures Releasing | false | false |
| 15 | 14 | Shrek Forever After | $67,272 | +4.5% | 109 | -7 | $617 | $6,952,025 | 11 | Universal Pictures International (UPI) | false | false |
| 16 | 15 | The Secret in Their Eyes | $53,169 | -11.9% | 14 | - | $3,797 | $352,866 | 4 | Wild Bunch Distribution | false | false |
| 17 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $50,806 | +29.9% | 70 | -4 | $725 | $1,327,877 | 8 | Warner Bros. | false | false |
| 18 | 16 | I Am Love | $48,475 | -9.2% | 16 | - | $3,029 | $357,455 | 4 | Cinéart | false | false |
| 19 | 11 | Dinner for Schmucks | $46,723 | -39.7% | 49 | - | $953 | $773,202 | 4 | Universal Pictures International (UPI) | false | false |
| 20 | - | Splice 2010 Re-release | $30,218 | - | 11 | - | $2,747 | $49,641 | 1 | Benelux Film Distributors | true | false |
