| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $249,844 | - | 30 | - | $8,328 | $249,844 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | I Do | $225,821 | - | 86 | - | $2,625 | $892,290 | 2 | Star Cinema | false | false |
| 3 | - | Piranha 3D | $212,135 | - | 30 | - | $7,071 | $212,135 | 1 | Viva International Pictures | true | false |
| 4 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $171,097 | -59.6% | 78 | - | $2,193 | $1,255,485 | 3 | Warner Bros. | false | false |
| 5 | - | The Town | $142,948 | - | 22 | - | $6,497 | $142,948 | 1 | Warner Bros. | true | false |
| 6 | 2 | Wall Street: Money Never Sleeps | $77,858 | -68.3% | 36 | -27 | $2,162 | $364,225 | 2 | 20th Century Fox International | false | false |
| 7 | 3 | Resident Evil: Afterlife | $59,626 | -43.2% | 28 | -32 | $2,129 | $2,017,838 | 5 | Pioneer Films | false | false |
| 8 | 5 | Devil | $42,971 | -16.5% | 17 | - | $2,527 | $227,026 | 3 | United International Pictures | false | false |
| 9 | 4 | Charlie St. Cloud | $28,198 | -71.2% | 17 | - | $1,658 | $126,064 | 2 | United International Pictures | false | false |
| 10 | 6 | Despicable Me | $13,261 | -57% | 11 | -8 | $1,205 | $2,243,587 | 6 | United International Pictures | false | false |
| 11 | 8 | Vampires Suck | $9,553 | -20% | 11 | - | $868 | $329,962 | 7 | 20th Century Fox International | false | false |
| 12 | 7 | After.Life | $7,231 | -51.2% | 15 | -2 | $482 | $77,920 | 3 | Pioneer Films | false | false |
| 13 | 9 | The Last Exorcism | $5,862 | -45.4% | 5 | -2 | $1,172 | $331,775 | 6 | Pioneer Films | false | false |
| 14 | 10 | Going the Distance | $2,523 | -56.6% | 6 | -1 | $420 | $467,855 | 6 | Warner Bros. | false | false |
