| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Megamind | $309,313 | - | 78 | - | $3,965 | $653,896 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Harry Potter and the Deathly Hallows: Part 1 | $194,526 | -51% | 72 | - | $2,701 | $2,025,767 | 3 | Warner Bros. | false | false |
| 3 | 3 | Devil | $106,815 | -34.5% | 40 | - | $2,670 | $340,239 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | The Social Network | $84,479 | - | 31 | - | $2,725 | $84,479 | 1 | Sony Pictures Releasing | true | false |
| 5 | - | The Joneses | $56,278 | - | 20 | - | $2,813 | $56,278 | 1 | N/A | true | false |
| 6 | - | Cell 211 | $34,945 | - | 20 | - | $1,747 | $34,945 | 1 | N/A | true | false |
| 7 | 4 | Hachi: A Dog's Tale | $13,802 | -61% | 34 | - | $405 | $355,313 | 4 | N/A | false | false |
| 8 | 5 | Ex | $12,984 | -45% | 8 | - | $1,623 | $81,610 | 3 | N/A | false | false |
| 9 | 7 | Due Date | $7,103 | -57.4% | 23 | - | $308 | $236,581 | 5 | Warner Bros. | false | false |
| 10 | 8 | Life as We Know It | $6,808 | -42.7% | 26 | - | $261 | $442,363 | 6 | Warner Bros. | false | false |
| 11 | - | The Girl with the Dragon Tattoo | $6,383 | - | 12 | - | $531 | $41,209 | 2 | N/A | false | false |
| 12 | 6 | Paranormal Activity 2 | $6,097 | -73% | 40 | - | $152 | $961,947 | 5 | Paramount Pictures International | false | false |
| 13 | 10 | Avatar 2010 Special Edition | $3,653 | -18.5% | 7 | - | $521 | $238,951 | 5 | 20th Century Fox International | false | false |
| 14 | 14 | Takers 2010 Re-release | $2,491 | +353.7% | 3 | +2 | $830 | $79,560 | 8 | Sony Pictures Releasing | false | false |
| 15 | 12 | Eat Pray Love | $1,730 | -41.1% | 1 | -1 | $1,730 | $322,855 | 7 | Sony Pictures Releasing | false | false |
| 16 | 9 | The Grudge 3 | $1,539 | -85.5% | 18 | - | $85 | $143,782 | 4 | N/A | false | false |
| 17 | 16 | Nanny McPhee Returns | $730 | +126% | 34 | - | $21 | $591,121 | 10 | Universal Pictures International (UPI) | false | false |
| 18 | 11 | Myths and Legends: The New Alliance | $622 | -84.1% | 22 | - | $28 | $106,569 | 4 | N/A | false | false |
| 19 | 17 | Machete | $404 | +27% | 2 | -1 | $202 | $74,706 | 4 | Sony Pictures Releasing | false | false |
| 20 | 13 | The Town | $175 | -85.3% | 25 | - | $7 | $243,273 | 7 | Warner Bros. | false | false |
| 21 | 15 | Legend of the Guardians: The Owls of Ga'Hoole | $127 | -69.8% | 46 | - | $2 | $1,330,099 | 9 | Warner Bros. | false | false |
